[HTML][HTML] Resources and computational strategies to advance small molecule SARS-CoV-2 discovery: Lessons from the pandemic and preparing for future health …

N Singh, BO Villoutreix - Computational and Structural Biotechnology …, 2021 - Elsevier
There is an urgent need to identify new therapies that prevent SARS-CoV-2 infection and
improve the outcome of COVID-19 patients. This pandemic has thus spurred intensive …

SARS-CoV-2 ORF9c is a membrane-associated protein that suppresses antiviral responses in cells

A Dominguez Andres, Y Feng, AR Campos, J Yin… - BioRxiv, 2020 - biorxiv.org
Disrupted antiviral immune responses are associated with severe COVID-19, the disease
caused by SAR-CoV-2. Here, we show that the 73-amino-acid protein encoded by ORF9c of …

Pathogenetic profiling of COVID-19 and SARS-like viruses

Z Nain, HK Rana, P Liò, SMS Islam… - Briefings in …, 2021 - academic.oup.com
Abstract The novel coronavirus (2019-nCoV) has recently emerged, causing COVID-19
outbreaks and significant societal/global disruption. Importantly, COVID-19 infection …

Dual spatially resolved transcriptomics for human host–pathogen colocalization studies in FFPE tissue sections

H Sounart, E Lázár, Y Masarapu, J Wu, T Várkonyi… - Genome Biology, 2023 - Springer
Technologies to study localized host–pathogen interactions are urgently needed. Here, we
present a spatial transcriptomics approach to simultaneously capture host and pathogen …

Flow blockage disrupts cilia-driven fluid transport in the epileptic brain

RJ Faubel, VS Santos Canellas, J Gaesser… - Acta …, 2022 - Springer
A carpet of ependymal motile cilia lines the brain ventricular system, forming a network of
flow channels and barriers that pattern cerebrospinal fluid (CSF) flow at the surface. This …

Identifying diseases associated with Post-COVID syndrome through an integrated network biology approach

N Krishna, S KP, R GK - Journal of Biomolecular Structure and …, 2024 - Taylor & Francis
A growing body of research shows that COVID-19 is now recognized as a multi-organ
disease with a wide range of manifestations that can have long-lasting repercussions …

Proteomic analysis of lung responses to SARS-CoV-2 infection in aged non-human primates: clinical and research relevance

A Garcia-Vilanova, A Allué-Guardia, NM Chacon… - GeroScience, 2024 - Springer
With devastating health and socioeconomic impact worldwide, much work is left to
understand the Coronavirus Disease 2019 (COVID-19), with emphasis in the severely …

[HTML][HTML] Investigating the human protein-host protein interactome of SARS-CoV-2 infection in the small intestine

M Khodadoost, Z Niknam, M Farahani… - … and Hepatology From …, 2020 - ncbi.nlm.nih.gov
Aim: The present study aimed to identify human protein–host protein interactions of SARS-
CoV-2 infection in the small intestine to discern the potential mechanisms and gain insights …

Malignant peritoneal mesothelioma interactome with 417 novel protein–protein interactions

KB Karunakaran, MK Ganapathiraju - BJC Reports, 2024 - nature.com
Abstract Background Malignant peritoneal mesothelioma (MPeM) is an aggressive cancer
affecting the abdominal peritoneal lining and intra-abdominal organs, with a median survival …

Potential involvement of protein phosphatase PP2CA on protein synthesis and cell cycle during SARS-CoV-2 infection. A meta analysis investigation

LP Otvos, GIM Garrito, LESF Machado - bioRxiv, 2023 - biorxiv.org
Coronavirus disease 2019 is a multi-systemic syndrome that caused a pandemic. Proteomic
studies demonstrate changes in protein expression and interaction involved in signaling …