Vaccine adjuvants: mechanisms and platforms

T Zhao, Y Cai, Y Jiang, X He, Y Wei, Y Yu… - Signal transduction and …, 2023 - nature.com
Adjuvants are indispensable components of vaccines. Despite being widely used in
vaccines, their action mechanisms are not yet clear. With a greater understanding of the …

Peptide hydrogels as immunomaterials and their use in cancer immunotherapy delivery

N Falcone, M Ermis, DG Tamay… - Advanced …, 2023 - Wiley Online Library
Peptide‐based hydrogel biomaterials have emerged as an excellent strategy for immune
system modulation. Peptide‐based hydrogels are supramolecular materials that self …

RNA origami functions as a self-adjuvanted nanovaccine platform for cancer immunotherapy

T Yip, X Qi, H Yan, Y Chang - ACS nano, 2024 - ACS Publications
Peptide-based vaccines have been widely investigated in cancer immunotherapy. Despite
their high specificity, safety, and low production cost, these vaccines have shown limited …

Injectable Nano-in-Gel Vaccine for Spatial and Temporal Control of Vaccine Kinetics and Breast Cancer Postsurgical Therapy

T Liu, X Si, L Liu, S Ma, Z Huang, Y Zhang, W Song… - ACS …, 2024 - ACS Publications
Breast cancer is the most commonly diagnosed cancer, and surgical resection is the first
choice for its treatment. With the development of operation techniques, surgical treatment for …

Gene therapy for urea cycle defects: An update from historical perspectives to future prospects

C Duff, IE Alexander, J Baruteau - Journal of Inherited …, 2024 - Wiley Online Library
Urea cycle defects (UCDs) are severe inherited metabolic diseases with high unmet needs
which present a permanent risk of hyperammonaemic decompensation and subsequent …

Responsive microneedles as a new platform for precision immunotherapy

X Liu, H Song, T Sun, H Wang - Pharmaceutics, 2023 - mdpi.com
Microneedles are a well-known transdermal or transdermal drug delivery system. Different
from intramuscular injection, intravenous injection, etc., the microneedle delivery system …

Broad and Durable Humoral Responses Following Single Hydrogel Immunization of SARS‐CoV‐2 Subunit Vaccine

BS Ou, OM Saouaf, J Yan, TUJ Bruun… - Advanced …, 2023 - Wiley Online Library
Most vaccines require several immunizations to induce robust immunity, and indeed, most
SARS‐CoV‐2 vaccines require an initial two‐shot regimen followed by several boosters to …

Enhancing the effect of nucleic acid vaccines in the treatment of HPV-related cancers: an overview of delivery systems

IA de Moura, AJD Silva, LS de Macêdo, MCV Invenção… - Pathogens, 2022 - mdpi.com
Prophylactic vaccines against human papillomavirus (HPV) have proven efficacy in those
who have not been infected by the virus. However, they do not benefit patients with …

Lung metastasis-Harnessed in-Situ adherent porous organic nanosponge-mediated antigen capture for A self-cascaded detained dendritic cells and T cell infiltration

TH Wu, YJ Lu, MR Chiang, PH Chen, YS Lee, MY Shen… - Biomaterials, 2024 - Elsevier
The infiltration of cytotoxic T lymphocytes promises to suppress the most irresistible
metastatic tumor for immunotherapy, yet immune privilege and low immunogenic responses …

A scalable synthesis of adjuvanting antigen depots based on metal–organic frameworks

RN Ehrman, OR Brohlin, YH Wijesundara… - Chemical …, 2024 - pubs.rsc.org
Vaccines have saved countless lives by preventing and even irradicating infectious
diseases. Commonly used subunit vaccines comprising one or multiple recombinant …