Research progress of natural matrine compounds and synthetic matrine derivatives

J Li, S Wei, D Marabada, Z Wang, Q Huang - Molecules, 2023 - mdpi.com
Matrine is a quinoline alkaloid extracted and separated from the dried root, fruit, and other
parts of the plant Sophora flavescens using an organic solvent. Matrine exhibits a variety of …

Quinolizidine-type alkaloids: chemodiversity, occurrence, and bioactivity

W Cely-Veloza, MJ Kato, E Coy-Barrera - ACS omega, 2023 - ACS Publications
Quinolizidine alkaloids (QAs) are nitrogen-containing compounds produced naturally as
specialized metabolites distributed in plants and animals (eg, frogs, sponges). The present …

Sophflarine A, a novel matrine-derived alkaloid from Sophora flavescens with therapeutic potential for non-small cell lung cancer through ROS-mediated pyroptosis …

D Luo, X Dai, H Tian, C Fan, H Xie, N Chen, J Wang… - Phytomedicine, 2023 - Elsevier
Background Novel compounds and more efficient treatment options are urgently needed for
the treatment of non-small cell lung cancer (NSCLC). The decoction of Sophora flavescens …

Discovery of hepatoprotective activity components from Thymus quinquecostatus celak. by molecular networking, biological evaluation and molecular dynamics …

X Zhong, R Song, D Shan, X Ren, Y Zheng, F Lv… - Bioorganic …, 2023 - Elsevier
Thymus quinquecostatus Celak. is an edible herb that widely cultivated in Asia and
possesses hepatoprotective activity, but the underlying non-volatile components of this …

Chemical construction and anti-HCoV-OC43 evaluation of novel 10, 12-disubstituted aloperine derivatives as dual cofactor inhibitors of TMPRSS2 and SR-B1

Y Shi, F Chen, M Wu, X Zhang, R Meng, K Wang… - Chinese Chemical …, 2024 - Elsevier
Abstract Thirty-one new 10, 12-disubstituted aloperine derivatives were subtly constructed
through a selective oxidation on the 10-α-C–H induced by sulfonyl and a nucleophilic …

Five quinolizidine alkaloids with anti-tobacco mosaic virus activities from two species of Sophora

J Zhang, T Zhang, Q An, P Zhang, CY Tian… - Chinese Chemical …, 2024 - Elsevier
Three novel matrine-type alkaloids (1–3) and two unprecedented aloperine-type alkaloids (4
and 5) were isolated from the root of Sophora tonkinensis and the seeds of Sophora …

Gold-catalyzed endo-selective cyclization of alkynylcyclobutanecarboxamides: synthesis of cyclobutane-fused dihydropyridones

MS Garre, GG Otárola, E Merino, D Sucunza… - Organic & …, 2023 - pubs.rsc.org
Cyclobutane-fused dihydropyridones can be efficiently synthesized by a completely endo-
selective gold-catalyzed cyclization of alkynylcyclobutanes bearing an appended amide …

(±)-Thymutatusone A, a pair of novel skeleton diterpene from Thymus quinquecostatus and in vitro hepatoprotective activity

M She - Authorea Preprints, 2024 - techrxiv.org
A pair of novel skeleton diterpenoid enantiomers,(+)-and (−)-thymutatusone A [(+)-and (−)-1],
along with one new and one known biogenetically related compounds (2-3), were isolated …