The OpenGATE ecosystem for Monte Carlo simulation in medical physics

D Sarrut, T Baudier, D Borys, A Etxebeste… - Physics in Medicine …, 2022 - iopscience.iop.org
This paper reviews the ecosystem of GATE, an open-source Monte Carlo toolkit for medical
physics. Based on the shoulders of Geant4, the principal modules (geometry, physics …

[HTML][HTML] Production review of accelerator-based medical isotopes

Y Wang, D Chen, R dos Santos Augusto, J Liang, Z Qin… - Molecules, 2022 - mdpi.com
The production of reactor-based medical isotopes is fragile, which has meant supply
shortages from time to time. This paper reviews alternative production methods in the form of …

[HTML][HTML] Recent Advances in 64Cu/67Cu-Based Radiopharmaceuticals

OO Krasnovskaya, D Abramchuck, A Erofeev… - International Journal of …, 2023 - mdpi.com
Copper-64 (T1/2= 12.7 h) is a positron and beta-emitting isotope, with decay characteristics
suitable for both positron emission tomography (PET) imaging and radiotherapy of cancer …

64Cu Treatment Planning and 67Cu Therapy with Radiolabeled [64Cu/67Cu] MeCOSar-Octreotate in Subjects with Unresectable Multifocal Meningioma: Initial …

DL Bailey, KP Willowson, M Harris… - Journal of Nuclear …, 2023 - Soc Nuclear Med
Our aim was to report the use of 64Cu and 67Cu as a theranostic pair of radionuclides in
human subjects. An additional aim was to measure whole-organ dosimetry of 64Cu and …

The predictive value of pretherapy [68Ga]Ga-DOTA-TATE PET and biomarkers in [177Lu]Lu-PRRT tumor dosimetry

A Akhavanallaf, AB Peterson, K Fitzpatrick… - European Journal of …, 2023 - Springer
Abstract Purpose Metastatic neuroendocrine tumors (NETs) overexpressing type 2
somatostatin receptors are the target for peptide receptor radionuclide therapy (PRRT) …

Radiation dosimetry, artificial intelligence and digital twins: old dog, new tricks

GM Currie, EM Rohren - Seminars in Nuclear Medicine, 2023 - Elsevier
Developments in artificial intelligence, particularly convolutional neural networks and deep
learning, have the potential for problem solving that has previously confounded human …

Copper and Copper Complexes in Tumor Therapy

Y Wang, T Tang, Y Yuan, N Li, X Wang… - ChemMedChem, 2024 - Wiley Online Library
Copper (Cu), a crucial trace element in physiological processes, has garnered significant
interest for its involvement in cancer progression and potential therapeutic applications. The …

Evaluation of the Effect of Macrocyclic Ring Size on [203Pb]Pb(II) Complex Stability in Pyridyl-Containing Chelators

BL McNeil, KJ Kadassery, AW McDonagh… - Inorganic …, 2022 - ACS Publications
As an element-equivalent theranostic pair, lead-203 (203Pb, 100% EC, half-life= 51.92 h)
and lead-212 (212Pb, 100% β–, half-life= 10.64 h), through the emission of γ rays and an α …

Theranostic Surrogacy of [123I]NaI for Differentiated Thyroid Cancer Radionuclide Therapy

SB Kim, MS Lee, IH Song, HS Park… - Molecular …, 2023 - ACS Publications
Precise dosimetry has gained interest for interpreting the response assessments of novel
therapeutic radiopharmaceuticals, as well as for improving conventional radiotherapies such …

Comparative Study of a Decadentate Acyclic Chelate, HOPO-O10, and Its Octadentate Analogue, HOPO-O8, for Radiopharmaceutical Applications

I Carbo-Bague, C Li, BL McNeil, Y Gao… - Inorganic …, 2023 - ACS Publications
Radiolanthanides and actinides are aptly suited for the diagnosis and treatment of cancer
via nuclear medicine because they possess unique chemical and physical properties (eg …