Genistein: an integrative overview of its mode of action, pharmacological properties, and health benefits
Genistein is an isoflavone first isolated from the brooming plant Dyer's Genista tinctoria L.
and is widely distributed in the Fabaceae family. As an isoflavone, mammalian genistein …
and is widely distributed in the Fabaceae family. As an isoflavone, mammalian genistein …
Targeting Cdc20 as a novel cancer therapeutic strategy
Abstract The Anaphase Promoting Complex (APC, also called APC/C) regulates cell cycle
progression by forming two closely related, but functionally distinct E3 ubiquitin ligase sub …
progression by forming two closely related, but functionally distinct E3 ubiquitin ligase sub …
Cdc20: at the crossroads between chromosome segregation and mitotic exit
M Kapanidou, NL Curtis, VM Bolanos-Garcia - Trends in biochemical …, 2017 - cell.com
Cell-division cycle protein 20 homologue (Cdc20) has important functions in chromosome
segregation and mitotic exit. Cdc20 is the target of the spindle assembly checkpoint (SAC) …
segregation and mitotic exit. Cdc20 is the target of the spindle assembly checkpoint (SAC) …
Targeting Cdc20 for cancer therapy
Abstract The Anaphase-Promoting Complex/Cyclosome (APC/C), an E3 ubiquitin ligase,
and two co-activators, Cdc20 and Cdh1, enable the ubiquitin-dependent proteasomal …
and two co-activators, Cdc20 and Cdh1, enable the ubiquitin-dependent proteasomal …
[HTML][HTML] Dietary intervention by phytochemicals and their role in modulating coding and non-coding genes in cancer
Phytochemicals are natural compounds synthesized as secondary metabolites in plants,
representing an important source of molecules with a wide range of therapeutic applications …
representing an important source of molecules with a wide range of therapeutic applications …
Flavonoids, bioactive components of propolis, exhibit cytotoxic activity and induce cell cycle arrest and apoptosis in human breast cancer cells MDA-MB-231 and MCF …
A Kabala-Dzik, A Rzepecka-Stojko, R Kubina… - Cellular and Molecular …, 2018 - air.unimi.it
Breast cancer is one of the most common causes of mortality in women. Flavonoids, among
other compounds, are bioactive constituents of propolis. In this comparative study, we …
other compounds, are bioactive constituents of propolis. In this comparative study, we …
[HTML][HTML] A review of twenty years of research on the regulation of signaling pathways by natural products in breast cancer
Breast cancer (BC) is the second leading cause of death among women, and it has become
a global health issue due to the increasing number of cases. Different treatment options …
a global health issue due to the increasing number of cases. Different treatment options …
[HTML][HTML] Role of natural compounds in preventing and treating breast cancer
B Noel, SK Singh, JW Lillard Jr… - Frontiers in bioscience …, 2020 - ncbi.nlm.nih.gov
Breast cancer (BrCa) is the most commonly diagnosed cancer and the second leading
cause of cancer-related death in women. Alarming increases in the cases quests for more …
cause of cancer-related death in women. Alarming increases in the cases quests for more …
[HTML][HTML] Genistein inhibits migration and invasion of cervical cancer HeLa cells by regulating FAK-paxillin and MAPK signaling pathways
C Chen, Y Wang, S Chen, X Ruan, H Liao… - Taiwanese Journal of …, 2020 - Elsevier
Objective Genistein obviously inhibits the migration and invasion of various tumor cells.
However, its effects on cervical cancer cells have seldom been referred. We aimed to …
However, its effects on cervical cancer cells have seldom been referred. We aimed to …
Cell division cycle 20 promotes cell proliferation and invasion and inhibits apoptosis in osteosarcoma cells
G Shang, X Ma, G Lv - Cell cycle, 2018 - Taylor & Francis
Cdc20 (cell division cycle 20 homologue) has been reported to exhibit an oncogenic role in
human tumorigenesis. However, the function of Cdc20 in osteosarcoma (OS) has not been …
human tumorigenesis. However, the function of Cdc20 in osteosarcoma (OS) has not been …