The genetics of bipolar disorder
FJA Gordovez, FJ McMahon - Molecular psychiatry, 2020 - nature.com
Bipolar disorder (BD) is one of the most heritable mental illnesses, but the elucidation of its
genetic basis has proven to be a very challenging endeavor. Genome-Wide Association …
genetic basis has proven to be a very challenging endeavor. Genome-Wide Association …
Multivariate meta-analyses of mitochondrial complex I and IV in major depressive disorder, bipolar disorder, schizophrenia, Alzheimer disease, and Parkinson disease
Abstract Complex I (NADH dehydrogenase, NDU) and complex IV (cytochrome-c-oxidase,
COX) of the mitochondrial electron transport chain have been implicated in the …
COX) of the mitochondrial electron transport chain have been implicated in the …
Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder
INTRODUCTION Our understanding of the pathophysiology of psychiatric disorders,
including autism spectrum disorder (ASD), schizophrenia (SCZ), and bipolar disorder (BD) …
including autism spectrum disorder (ASD), schizophrenia (SCZ), and bipolar disorder (BD) …
Amygdala and anterior cingulate transcriptomes from individuals with bipolar disorder reveal downregulated neuroimmune and synaptic pathways
Recent genetic studies have identified variants associated with bipolar disorder (BD), but it
remains unclear how brain gene expression is altered in BD and how genetic risk for BD …
remains unclear how brain gene expression is altered in BD and how genetic risk for BD …
Postmortem evidence of brain inflammatory markers in bipolar disorder: a systematic review
VV Giridharan, P Sayana, OF Pinjari, N Ahmad… - Molecular …, 2020 - nature.com
Bipolar disorder (BD) is a chronic affective disorder with extreme mood swings that include
mania or hypomania and depression. Though the exact mechanism of BD is unknown …
mania or hypomania and depression. Though the exact mechanism of BD is unknown …
Inflammation-related transcripts define “high” and “low” subgroups of individuals with schizophrenia and bipolar disorder in the midbrain
Dopamine dysregulation in schizophrenia may be associated with midbrain inflammation.
Previously, we found elevated levels of pro-inflammatory cytokine mRNAs in the post …
Previously, we found elevated levels of pro-inflammatory cytokine mRNAs in the post …
DC vaccines loaded with glioma cells killed by photodynamic therapy induce Th17 anti-tumor immunity and provide a four-gene signature for glioma prognosis
M Vedunova, V Turubanova, O Vershinina… - Cell Death & …, 2022 - nature.com
Gliomas, the most frequent type of primary tumor of the central nervous system in adults,
results in significant morbidity and mortality. Despite the development of novel, complex …
results in significant morbidity and mortality. Despite the development of novel, complex …
[HTML][HTML] Transcriptomic insight into the polygenic mechanisms underlying psychiatric disorders
Over the past decade, large-scale genetic studies have successfully identified hundreds of
genetic variants robustly associated with risk for psychiatric disorders. However, mechanistic …
genetic variants robustly associated with risk for psychiatric disorders. However, mechanistic …
Circadian regulation of the neuroimmune environment across the lifespan: from brain development to aging
Circadian clocks confer 24-h periodicity to biological systems, to ultimately maximize energy
efficiency and promote survival in a world with regular environmental light cycles. In …
efficiency and promote survival in a world with regular environmental light cycles. In …
Sex-dependent neurobiological features of prenatal immune activation via TLR7
G Missig, JO Robbins, EL Mokler, KM McCullough… - Molecular …, 2020 - nature.com
Immune activation during pregnancy via infection or autoimmune disease is a risk factor for
neuropsychiatric illness. Mouse models of prenatal immune activation often involve maternal …
neuropsychiatric illness. Mouse models of prenatal immune activation often involve maternal …