Ginger and its pungent constituents non‐competitively inhibit activation of human recombinant and native 5‐HT3 receptors of enteric neurons

J Walstab, D Krüger, T Stark, T Hofmann… - …, 2013 - Wiley Online Library
Background Beneficial effects of ginger in the treatment of gastrointestinal (GI) problems and
chemotherapy‐induced nausea and vomiting are well accepted. In rodents, the action of …

Therapeutics of 5-HT3 receptor antagonists: current uses and future directions

TK Machu - Pharmacology & therapeutics, 2011 - Elsevier
The 5-Hydroxytryptamine3 (5-HT3) receptor is a member of the cys-loop family of ligand
gated ion channels, of which the nicotinic acetylcholine receptor is the prototype. All other 5 …

The auspicious role of the 5-HT3 receptor in depression: a probable neuronal target?

R Rajkumar, R Mahesh - Journal of psychopharmacology, 2010 - journals.sagepub.com
The serotonergic mechanisms have been successfully utilized by the majority of
antidepressant drug discovery programmes, while the search for newer targets remains …

Atomic force microscopy reveals the stoichiometry and subunit arrangement of 5-HT3 receptors

NP Barrera, P Herbert, RM Henderson… - Proceedings of the …, 2005 - National Acad Sciences
The 5-HT3 receptor is a cation-selective ligand-gated ion channel of the Cys-loop
superfamily. The receptor is an important therapeutic target, with receptor antagonists being …

5-HT3 Receptors on Mitochondria Influence Mitochondrial Function

STRB Rao, I Turek, J Ratcliffe, S Beckham… - International Journal of …, 2023 - mdpi.com
The 5-hydroxytryptamine 3 (5-HT3) receptor belongs to the pentameric ligand-gated cation
channel superfamily. Humans have five different 5-HT3 receptor subunits: A to E. The 5-HT3 …

Pet-1 switches transcriptional targets postnatally to regulate maturation of serotonin neuron excitability

SC Wyler, WC Spencer, NH Green… - Journal of …, 2016 - Soc Neuroscience
Newborn neurons enter an extended maturation stage, during which they acquire excitability
characteristics crucial for development of presynaptic and postsynaptic connectivity. In …

Serotonin 5-HT3 receptors in the central nervous system

P Chameau, JA van Hooft - Cell and tissue research, 2006 - Springer
The 5-HT 3 receptor is a ligand-gated ion channel activated by serotonin (5-HT). Although
originally identified in the peripheral nervous system, the 5-HT 3 receptor is also …

Role of 5-HT3 Receptors in the Antidepressant Response

C Bétry, A Etiévant, C Oosterhof, B Ebert, C Sanchez… - Pharmaceuticals, 2011 - mdpi.com
Serotonin (5-HT) 3 receptors are the only ligand-gated ion channel of the 5-HT receptors
family. They are present both in the peripheral and central nervous system and are localized …

Physiology and pathophysiology of the 5‐HT3 receptor

L Färber, U Haus, M Späth… - Scandinavian Journal of …, 2004 - Taylor & Francis
The 5‐HT3 receptor is a ligand‐gated cation channel located in the central and peripheral
nervous system; it has also been detected on a variety of other cells. In the periphery, it is …

Alu Recombination-Mediated Structural Deletions in the Chimpanzee Genome

K Han, J Lee, TJ Meyer, J Wang, SK Sen… - PLoS …, 2007 - journals.plos.org
With more than 1.2 million copies, Alu elements are one of the most important sources of
structural variation in primate genomes. Here, we compare the chimpanzee and human …