Ginger and its pungent constituents non‐competitively inhibit activation of human recombinant and native 5‐HT3 receptors of enteric neurons
J Walstab, D Krüger, T Stark, T Hofmann… - …, 2013 - Wiley Online Library
Background Beneficial effects of ginger in the treatment of gastrointestinal (GI) problems and
chemotherapy‐induced nausea and vomiting are well accepted. In rodents, the action of …
chemotherapy‐induced nausea and vomiting are well accepted. In rodents, the action of …
Therapeutics of 5-HT3 receptor antagonists: current uses and future directions
TK Machu - Pharmacology & therapeutics, 2011 - Elsevier
The 5-Hydroxytryptamine3 (5-HT3) receptor is a member of the cys-loop family of ligand
gated ion channels, of which the nicotinic acetylcholine receptor is the prototype. All other 5 …
gated ion channels, of which the nicotinic acetylcholine receptor is the prototype. All other 5 …
The auspicious role of the 5-HT3 receptor in depression: a probable neuronal target?
R Rajkumar, R Mahesh - Journal of psychopharmacology, 2010 - journals.sagepub.com
The serotonergic mechanisms have been successfully utilized by the majority of
antidepressant drug discovery programmes, while the search for newer targets remains …
antidepressant drug discovery programmes, while the search for newer targets remains …
Atomic force microscopy reveals the stoichiometry and subunit arrangement of 5-HT3 receptors
NP Barrera, P Herbert, RM Henderson… - Proceedings of the …, 2005 - National Acad Sciences
The 5-HT3 receptor is a cation-selective ligand-gated ion channel of the Cys-loop
superfamily. The receptor is an important therapeutic target, with receptor antagonists being …
superfamily. The receptor is an important therapeutic target, with receptor antagonists being …
5-HT3 Receptors on Mitochondria Influence Mitochondrial Function
The 5-hydroxytryptamine 3 (5-HT3) receptor belongs to the pentameric ligand-gated cation
channel superfamily. Humans have five different 5-HT3 receptor subunits: A to E. The 5-HT3 …
channel superfamily. Humans have five different 5-HT3 receptor subunits: A to E. The 5-HT3 …
Pet-1 switches transcriptional targets postnatally to regulate maturation of serotonin neuron excitability
SC Wyler, WC Spencer, NH Green… - Journal of …, 2016 - Soc Neuroscience
Newborn neurons enter an extended maturation stage, during which they acquire excitability
characteristics crucial for development of presynaptic and postsynaptic connectivity. In …
characteristics crucial for development of presynaptic and postsynaptic connectivity. In …
Serotonin 5-HT3 receptors in the central nervous system
P Chameau, JA van Hooft - Cell and tissue research, 2006 - Springer
The 5-HT 3 receptor is a ligand-gated ion channel activated by serotonin (5-HT). Although
originally identified in the peripheral nervous system, the 5-HT 3 receptor is also …
originally identified in the peripheral nervous system, the 5-HT 3 receptor is also …
Role of 5-HT3 Receptors in the Antidepressant Response
Serotonin (5-HT) 3 receptors are the only ligand-gated ion channel of the 5-HT receptors
family. They are present both in the peripheral and central nervous system and are localized …
family. They are present both in the peripheral and central nervous system and are localized …
Physiology and pathophysiology of the 5‐HT3 receptor
L Färber, U Haus, M Späth… - Scandinavian Journal of …, 2004 - Taylor & Francis
The 5‐HT3 receptor is a ligand‐gated cation channel located in the central and peripheral
nervous system; it has also been detected on a variety of other cells. In the periphery, it is …
nervous system; it has also been detected on a variety of other cells. In the periphery, it is …
Alu Recombination-Mediated Structural Deletions in the Chimpanzee Genome
With more than 1.2 million copies, Alu elements are one of the most important sources of
structural variation in primate genomes. Here, we compare the chimpanzee and human …
structural variation in primate genomes. Here, we compare the chimpanzee and human …