The serotonin receptor type 3 is a pentameric ligand-gated ion channel regulating intestinal
motility, nausea, and vomiting in humans. The HTR3B gene codes for the subunit B of this …

Almost 10 years have passed since we wrote the review on the “Distribution of 5-HT
receptors in the central nervous system” in this series (Mengod, Cortés, Vilaró, & Hoyer …

The FDA-approved antidepressant and smoking cessation drug bupropion is known to
inhibit dopamine and norepinephrine reuptake transporters, as well as nicotinic …

Cys-loop receptors mediate rapid transmission throughout the nervous system by converting
a chemical signal into an electric one. They are pentameric proteins with an extracellular …

Neurotransmitter receptors of the Cys-loop superfamily mediate rapid synaptic transmission
throughout the nervous system, and include receptors activated by ACh, GABA, glycine and …

Although five 5-hydroxytryptamine type 3 (5-HT3) subunits (A–E) have been cloned,
knowledge on the regulation of their assembly is limited. RIC-3 has been identified as a …

The 5-HT 3 receptor is a member of the Cys-loop family of ligandgated ion channels. The
extracellular domains of these proteins contain six amino acid loops (A–F) that converge to …

Background and Purpose: The antimalarial compounds quinine, chloroquine and
mefloquine affect the electrophysiological properties of Cys‐loop receptors and have …

Cation-selective cysteine (Cys)-loop transmitter-gated ion channels provide an important
pathway for Ca 2+ entry into neurones. We examined the influence on Ca 2+ permeation of …

Obsessive-compulsive disorder (OCD) is a psychiatric condition that is characterized by
obsessive thoughts and compulsive behavior. Over the past decades, the involvement of the …