This review focuses on the multiple and reciprocal relationships that exist between oxidative
stress, hyperglycemia and diabetes and related metabolic disorders. Human metabolism …

Objective. Rhizoma Coptidis is an herb that has been frequently used in many traditional
formulas for the treatment of diabetic mellitus (DM) over thousands of years. Berberine, the …

CYP3A is an enzyme subfamily in the cytochrome P450 (CYP) superfamily and includes
isoforms CYP3A4, CYP3A5, CYP3A7, and CYP3A43. CYP3A enzymes are indiscriminate …

Background: Available in-vitro and animal studies indicate that inflammation impacts
cytochromes P450 (CYP) activity via multiple and complex transcriptional and post …

Changes in the pharmacokinetic and resulting pharmacodynamic properties of drugs are
common in many chronic liver diseases, leading to adverse effects, drug interactions and …

Diabetes mellitus (DM) represents a complex carbohydrate metabolism disorder
characterized by inflammatory over-reactivity. The study aimed to investigate the potential …

Oxycodone is a widely used opioid for the management of chronic pain. Analgesic effects
observed following the administration of oxycodone are mediated mostly by agonistic effects …

Introduction: Pharmacogenetics-informed drug prescribing is increasingly applied in clinical
practice. Typically, drug metabolizing phenotypes are determined based on genetic test …

Qingjin Yiqi granules (QJYQ granules) are hospital preparations derived from ancient
prescriptions under the guidance of academician Zhang Boli; they have the effect of …

A non-healing diabetic foot ulcer (DFU) is a debilitating clinical problem amounting to
socioeconomic and psychosocial burdens. DFUs increase morbidity due to prolonged …