TGR5 deficiency in excitatory neurons ameliorates Alzheimer's pathology by regulating APP processing
C Li, L Wang, W Xie, E Chen, Y Chen, H Li, D Can… - Science …, 2024 - science.org
Bile acids (BAs) metabolism has a significant impact on the pathogenesis of Alzheimer's
disease (AD). We found that deoxycholic acid (DCA) increased in brains of AD mice at an …
disease (AD). We found that deoxycholic acid (DCA) increased in brains of AD mice at an …
From bile acids to melancholia
AS Klein, MA Kheirbek - Neuron, 2024 - Elsevier
In this issue of Neuron, Li, Zhang, et al. 1 find that the bile acid receptor TGR5 in the lateral
hypothalamus influences neuronal dynamics underlying stress-induced depression-like …
hypothalamus influences neuronal dynamics underlying stress-induced depression-like …