The primate prefrontal cortex (PFC) subserves our highest order cognitive operations, and
yet is tremendously dependent on a precise neurochemical environment for proper …

Acetylcholine plays an essential role in fundamental aspects of cognition. Studies that have
mapped the activity and functional connectivity of cholinergic neurons have shown that the …

Noradrenergic and cholinergic systems are among the most vulnerable brain systems in
neuropsychiatric diseases of ageing, including Alzheimer's disease, Parkinson's disease …

The neocortex is densely innervated by basal forebrain (BF) cholinergic neurons. Long-
range axons of cholinergic neurons regulate higher-order cognitive function and dysfunction …

Spatial learning, including encoding and retrieval of spatial memories as well as holding
spatial information in working memory generally serving navigation under a broad range of …

Organisms process sensory information in the context of their own moving bodies, an idea
referred to as embodiment. This idea is important for developmental neuroscience, robotics …

ACh is a signaling molecule in the mammalian CNS, with well-documented influence over
cognition and behavior. However, the nature of cholinergic signaling in the brain remains …

Significant innovations in the management of acute ischemic stroke have led to an
increased incidence in the long-term complications of stroke. Therefore, there is an urgent …

Visual processing is dynamically controlled by multiple neuromodulatory molecules that
modify the responsiveness of neurons and the strength of the connections between them. In …

Deep brain stimulation (DBS) of the nucleus basalis of Meynert (NBM) has been clinically
investigated in Alzheimer's disease (AD) and Lewy body dementia (LBD). However, the …