The concept of strain in organic compounds is as old as modern organic chemistry and was
initially introduced to justify the synthetic setbacks along the synthesis of small ring systems …

Organoborons have emerged as versatile building blocks in organic synthesis to achieve
molecular diversity and as carboxylic acid bioisosteres with broad applicability in drug …

We report the use of photocatalysis for the homolytic ring-opening of carbonyl
cyclopropanes. In contrast to previous studies, our approach does not require a metal …

This review describes the development of enantioselective methods for the ring opening of
cyclopropanes. Both approaches based on the reaction of nonchiral cyclopropanes and …

Diacids are important monomers in the polymer industry to construct valuable materials.
Dicarboxylation of unsaturated bonds, such as alkenes and alkynes, with CO2 has been …

In this review, transition metal-catalyzed methodologies and applications that exploit C–C
bond cleavage of vinylcyclopropanes (VCPs) are summarized with a focus on cycloaddition …

Hexafluoroisopropanol (HFIP) is a solvent with unique properties that has recently gained
attention for promoting a wide range of challenging chemical reactions. It was initially …

Three-and four-membered rings, widespread motifs in nature and medicinal chemistry, have
fascinated chemists ever since their discovery. However, due to energetic considerations …

The development of two divergent and complementary Lewis acid catalyzed additions of
bicyclobutanes to imines is described. Microscale high‐throughput experimentation was …

Complex molecular architectures containing cyclopropanes present significant challenges
for any synthetic chemist. This review aims to highlight the strategic considerations for …