Genetics of common cerebral small vessel disease
Cerebral small vessel disease (cSVD) is a leading cause of ischaemic and haemorrhagic
stroke and a major contributor to dementia. Covert cSVD, which is detectable with brain MRI …
stroke and a major contributor to dementia. Covert cSVD, which is detectable with brain MRI …
Polygenic risk scores for the prediction of cardiometabolic disease
Cardiometabolic diseases contribute more to global morbidity and mortality than any other
group of disorders. Polygenic risk scores (PRSs), the weighted summation of individually …
group of disorders. Polygenic risk scores (PRSs), the weighted summation of individually …
[HTML][HTML] A multi-ancestry polygenic risk score improves risk prediction for coronary artery disease
Identification of individuals at highest risk of coronary artery disease (CAD)—ideally before
onset—remains an important public health need. Prior studies have developed genome …
onset—remains an important public health need. Prior studies have developed genome …
[HTML][HTML] Stroke genetics informs drug discovery and risk prediction across ancestries
Previous genome-wide association studies (GWASs) of stroke—the second leading cause of
death worldwide—were conducted predominantly in populations of European ancestry …
death worldwide—were conducted predominantly in populations of European ancestry …
LDpred2: better, faster, stronger
Motivation Polygenic scores have become a central tool in human genetics research.
LDpred is a popular method for deriving polygenic scores based on summary statistics and …
LDpred is a popular method for deriving polygenic scores based on summary statistics and …
The Polygenic Score Catalog as an open database for reproducibility and systematic evaluation
We present the Polygenic Score (PGS) Catalog (https://www. PGSCatalog. org), an open
resource of published scores (including variants, alleles and weights) and consistently …
resource of published scores (including variants, alleles and weights) and consistently …
Se‐containing MOF coated dual‐Fe‐atom nanozymes with multi‐enzyme cascade activities protect against cerebral ischemic reperfusion injury
R Tian, H Ma, W Ye, Y Li, S Wang… - Advanced Functional …, 2022 - Wiley Online Library
The atomically monodispersed dual‐atom nanozyme not only possesses the advantages of
homogeneous active centers and high atomic utilization efficiency but also exhibits amazing …
homogeneous active centers and high atomic utilization efficiency but also exhibits amazing …
A polygenic risk score improves risk stratification of coronary artery disease: a large-scale prospective Chinese cohort study
X Lu, Z Liu, Q Cui, F Liu, J Li, X Niu, C Shen… - European heart …, 2022 - academic.oup.com
Aims To construct a polygenic risk score (PRS) for coronary artery disease (CAD) and
comprehensively evaluate its potential in clinical utility for primary prevention in Chinese …
comprehensively evaluate its potential in clinical utility for primary prevention in Chinese …
[HTML][HTML] Polygenic risk scores in cardiovascular risk prediction: A cohort study and modelling analyses
Background Polygenic risk scores (PRSs) can stratify populations into cardiovascular
disease (CVD) risk groups. We aimed to quantify the potential advantage of adding …
disease (CVD) risk groups. We aimed to quantify the potential advantage of adding …
[HTML][HTML] Pan-cancer analysis demonstrates that integrating polygenic risk scores with modifiable risk factors improves risk prediction
L Kachuri, RE Graff, K Smith-Byrne, TJ Meyers… - Nature …, 2020 - nature.com
Cancer risk is determined by a complex interplay of environmental and heritable factors.
Polygenic risk scores (PRS) provide a personalized genetic susceptibility profile that may be …
Polygenic risk scores (PRS) provide a personalized genetic susceptibility profile that may be …