Future technology insight: mass spectrometry imaging as a tool in drug research and development
In pharmaceutical research, understanding the biodistribution, accumulation and
metabolism of drugs in tissue plays a key role during drug discovery and development. In …
metabolism of drugs in tissue plays a key role during drug discovery and development. In …
Clinical applications of MALDI imaging technologies in cancer and neurodegenerative diseases
Matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) imaging mass
spectrometry (IMS) enables localization of analytes of interest along with histology. More …
spectrometry (IMS) enables localization of analytes of interest along with histology. More …
Spatio-temporal metabolite profiling of the barley germination process by MALDI MS imaging
MALDI mass spectrometry imaging was performed to localize metabolites during the first
seven days of the barley germination. Up to 100 mass signals were detected of which 85 …
seven days of the barley germination. Up to 100 mass signals were detected of which 85 …
Mass spectrometry imaging reveals heterogeneous efavirenz distribution within putative HIV reservoirs
CG Thompson, MT Bokhart, C Sykes… - Antimicrobial agents …, 2015 - Am Soc Microbiol
Persistent HIV replication within active viral reservoirs may be caused by inadequate
antiretroviral penetration. Here, we used mass spectrometry imaging with infrared matrix …
antiretroviral penetration. Here, we used mass spectrometry imaging with infrared matrix …
Emerging role of clinical mass spectrometry in pathology
Mass spectrometry-based assays have been increasingly implemented in various
disciplines in clinical diagnostic laboratories for their combined advantages in multiplexing …
disciplines in clinical diagnostic laboratories for their combined advantages in multiplexing …
MALDI imaging mass spectrometry—a mini review of methods and recent developments
C Eriksson, N Masaki, I Yao, T Hayasaka… - Mass Spectrometry, 2013 - jstage.jst.go.jp
As the only imaging method available, Imaging Mass Spectrometry (IMS) can determine
both the identity and the distribution of hundreds of molecules on tissue sections, all in one …
both the identity and the distribution of hundreds of molecules on tissue sections, all in one …
Mapping drug distribution in brain tissue using liquid extraction surface analysis mass spectrometry imaging
JG Swales, JW Tucker, MJ Spreadborough… - Analytical …, 2015 - ACS Publications
Liquid extraction surface analysis mass spectrometry (LESA-MS) is a surface sampling
technique that incorporates liquid extraction from the surface of tissue sections with …
technique that incorporates liquid extraction from the surface of tissue sections with …
Mass spectrometry imaging of levofloxacin distribution in TB-infected pulmonary lesions by MALDI-MSI and continuous liquid microjunction surface sampling
A multi-modal mass spectrometry imaging (MSI) and profiling approach has been applied to
assess the partitioning of the anti-TB fluoroquinolone levofloxacin into pulmonary lesions …
assess the partitioning of the anti-TB fluoroquinolone levofloxacin into pulmonary lesions …
High-speed tandem mass spectrometric in situ imaging by nanospray desorption electrospray ionization mass spectrometry
Nanospray desorption electrospray ionization (nano-DESI) combined with tandem mass
spectrometry (MS/MS), high-resolution mass analysis of the fragment ions (m/Δ m= 17 500 at …
spectrometry (MS/MS), high-resolution mass analysis of the fragment ions (m/Δ m= 17 500 at …
Mass spectrometry imaging in zebrafish larvae for assessing drug safety and metabolism
M Asslan, N Lauzon, M Beus, D Maysinger… - Analytical and …, 2021 - Springer
Drug safety assessment in the early phases of drug discovery is critical to facilitate the rapid
development of novel therapeutics. Recently, teleost zebrafish (Danio rerio) has emerged as …
development of novel therapeutics. Recently, teleost zebrafish (Danio rerio) has emerged as …