Linkers or spacers are short amino acid sequences created in nature to separate multiple
domains in a single protein. Most of them are rigid and function to prohibit unwanted …

To provide a T-cell population that will respond promptly to foreign antigen, the immune
system looks inward, using the variety of self-antigens to select and maintain a diverse …

The endocrine pancreas is one of the most inaccessible organs of the human body. Its
autoimmune attack leads to type 1 diabetes (T1D) in a genetically susceptible population …

▪ Abstract Exciting breakthroughs in the last two years have begun to elucidate the structural
basis of cellular immune recognition. Crystal structures have been determined for full-length …

The OVA 323–339 epitope recognized by DO11. 10 (H-2 d) and OT-II (H-2 b) T cells was
investigated using amino-and carboxy-terminal truncations to locate the approximate ends …

The class II major histocompatibility complex (MHC) glycoproteins HLA-DQ8 and HLA-DQ2
in humans and IA g7 in nonobese diabetic (NOD) mice are the major risk factors for …

Exosomes are nanovesicles harboring proteins important for antigen presentation. We
compared the potency of differently loaded exosomes, directly loaded with OVA323-339 …

While much is known about intracellular signaling events in T cells when T cell receptors
(TCRs) are engaged, the mechanism by which signaling is initiated is unclear. We have …

The crystal structure of a complex involving the D10 T cell receptor (TCR), 16-residue
foreign peptide antigen, and the I-Ak self major histocompatibility complex (MHC) class II …

Susceptibility to multiple sclerosis is associated with the human histocompatibility leukocyte
antigen (HLA)-DR2 (DRB1* 1501) haplotype. The structure of HLA-DR2 was determined …