Abstract Casein kinase 2 (CK2) is a type of conserved serine/threonine protein kinase that
phosphorylates many important proteins in the eukaryotes. There are various research …

Acute myeloid leukemia (AML) has a high mortality rate and its clinical management
remains challenging. The aim of the present study was to identify the hub genes involved in …

A paradigm shift is emerging within the FOXO field and accumulating evidence indicates that
we need to reappreciate the role of FOXOs, at least in cancer development. Here, we …

Protein kinase CK2 is active in cancer cells. Previously, we reported that increased CK2
activity could induce epithelial mesenchymal transition of cancer cells. CK2 also induced …

Overexpression of casein kinase 2 (CK2) has an oncogenic and pro-survival role in many
cancers. CX-4945 (Silmitasertib) is a CK2 inhibitor with anti-cancerous and anti-angiogenic …

Background/Aim: Recently, we demonstrated the ability of inhibitors of protein kinase 2
(casein kinase II; CK2) to enhance the efficacy of 5-fluorouracil, a thymidylate synthase …

Abstract Background Leukemia stem cells (LSCs) are considered to be the cause of
treatment failure and relapse in acute myeloid leukemia (AML). Overexpression of the Bcl-2 …

Integrin-linked kinase (ILK) has emerged as a critical adaptor and mediator protein in cell
signaling pathways that is commonly deregulated in acute myeloid leukemia (AML). This …

Cell signaling is an important part of the complex system of molecular communication that
governs basic cellular activities and coordinates cell cycle machinery. Pathological …

Abstract Protein kinase CK2 (CK2) is a ubiquitous serine/threonine kinase with multiple
cellular functions in vertebrates including apoptosis, differentiation, proliferation, survival …