Prediction of drug side effects with a refined negative sample selection strategy
H Liang, L Chen, X Zhao… - … and Mathematical Methods …, 2020 - Wiley Online Library
Drugs are an important way to treat various diseases. However, they inevitably produce side
effects, bringing great risks to human bodies and pharmaceutical companies. How to predict …
effects, bringing great risks to human bodies and pharmaceutical companies. How to predict …
[HTML][HTML] Inferring anatomical therapeutic chemical (ATC) class of drugs using shortest path and random walk with restart algorithms
L Chen, T Liu, X Zhao - Biochimica et Biophysica Acta (BBA)-Molecular …, 2018 - Elsevier
The anatomical therapeutic chemical (ATC) classification system is a widely accepted drug
classification scheme. This system comprises five levels and includes several classes in …
classification scheme. This system comprises five levels and includes several classes in …
Identification of COVID‐19 infection‐related human genes based on a random walk model in a virus–human protein interaction network
Coronaviruses are specific crown‐shaped viruses that were first identified in the 1960s, and
three typical examples of the most recent coronavirus disease outbreaks include severe …
three typical examples of the most recent coronavirus disease outbreaks include severe …
[HTML][HTML] Arabidopsis thaliana serine hydroxymethyltransferases: functions, structures, and perspectives
I Nogués, B Sekula, S Angelaccio… - Plant Physiology and …, 2022 - Elsevier
Serine hydroxymethyltransferase (SHM) is one of the hallmarks of one-carbon metabolism.
In plants, isoforms of SHM participate in photorespiration and/or transfer the one-carbon unit …
In plants, isoforms of SHM participate in photorespiration and/or transfer the one-carbon unit …
[HTML][HTML] Genome-wide characterization and gene expression analyses of malate dehydrogenase (MDH) genes in low-phosphorus stress tolerance of Chinese fir …
Y Lin, W Chen, Q Yang, Y Zhang, X Ma… - International Journal of …, 2023 - mdpi.com
Malate dehydrogenase (MDH) genes play vital roles in developmental control and
environmental stress tolerance in sessile plants by modulating the organic acid–malic acid …
environmental stress tolerance in sessile plants by modulating the organic acid–malic acid …
Linkage and association study discovered loci and candidate genes for glycinin and β-conglycinin in soybean (Glycine max L. Merr.)
S Zhang, H Du, Y Ma, H Li, G Kan, D Yu - Theoretical and Applied …, 2021 - Springer
Key message Linkage mapping and GWAS identified 67 QTLs related to soybean glycinin, β-
conglycinin and relevant traits. Polymorphisms of the candidate gene Gy1 promoter were …
conglycinin and relevant traits. Polymorphisms of the candidate gene Gy1 promoter were …
[HTML][HTML] Network-based method for mining novel HPV infection related genes using random walk with restart algorithm
L Zhu, F Su, YC Xu, Q Zou - … et Biophysica Acta (BBA)-Molecular Basis of …, 2018 - Elsevier
The human papillomavirus (HPV), a common virus that infects the reproductive tract, may
lead to malignant changes within the infection area in certain cases and is directly …
lead to malignant changes within the infection area in certain cases and is directly …
A path-based method for identification of protein phenotypic annotations
J Gao, B Hu, L Chen - Current Bioinformatics, 2021 - ingentaconnect.com
Background: Identification of protein phenotypic annotations is an essential and challenging
problem in modern genetics. Such problem is related to some serious diseases, including …
problem in modern genetics. Such problem is related to some serious diseases, including …
[HTML][HTML] Identification of proliferative diabetic retinopathy-associated genes on the protein–protein interaction network by using heat diffusion algorithm
J Zhang, M Zhang, H Zhao, X Xu - … Acta (BBA)-Molecular Basis of Disease, 2020 - Elsevier
Diabetic retinopathy is a common complication of diabetes mellitus that causes pathogenic
damage to the retina. Particularly, the proliferative diabetic retinopathy (PDR) state can …
damage to the retina. Particularly, the proliferative diabetic retinopathy (PDR) state can …
[HTML][HTML] Large scale proteomic data and network-based systems biology approaches to explore the plant world
D Di Silvestre, A Bergamaschi, E Bellini, PL Mauri - Proteomes, 2018 - mdpi.com
The investigation of plant organisms by means of data-derived systems biology approaches
based on network modeling is mainly characterized by genomic data, while the potential of …
based on network modeling is mainly characterized by genomic data, while the potential of …