A molecular mimic demonstrates that phosphorylated human prolactin is a potent anti-angiogenic hormone

E Ueda, U Ozerdem, YH Chen, M Yao… - Endocrine-related …, 2006 - erc.bioscientifica.com
S179D prolactin (PRL) is an experimentally useful mimic of naturally phosphorylated human
prolactin. S179D PRL, but not unmodified PRL, was found to be anti-angiogenic in both the …

Lactogenic hormones stimulate expression of lipogenic genes but not glucose transporters in bovine mammary gland

Y Shao, EH Wall, TB McFadden, Y Misra, X Qian… - Domestic animal …, 2013 - Elsevier
During the onset of lactation, there is a dramatic increase in the expression of glucose
transporters (GLUT) and a group of enzymes involved in milk fat synthesis in the bovine …

Key stages in mammary gland development-The alveolar switch: coordinating the proliferative cues and cell fate decisions that drive the formation of lobuloalveoli …

SR Oakes, HN Hilton, CJ Ormandy - Breast Cancer Research, 2006 - Springer
Massive tissue remodelling occurs within the mammary gland during pregnancy, resulting in
the formation of lobuloalveoli that are capable of milk secretion. Endocrine signals …

Participation of mammary gland in long-chain polyunsaturated fatty acid synthesis during pregnancy and lactation in rats

M Rodriguez-Cruz, R Sánchez, AM Sánchez… - … et Biophysica Acta (BBA …, 2011 - Elsevier
Metabolic adaptations are triggered in the maternal organism to synthesize milk with an
adequate concentration of long-chain polyunsaturated fatty acids (LC-PUFAs) required to …

S179D prolactin: antagonistic agony!

AM Walker - Molecular and cellular endocrinology, 2007 - Elsevier
The aims of this review are three-fold: first, to collate what is known about the production and
activities of phosphorylated prolactin (PRL), the latter largely, but not exclusively, as …

[PDF][PDF] Regulation of gene expression in human mammary epithelium: effect of breast pumping

PD Maningat, P Sen, AL Sunehag… - Journal of …, 2007 - researchgate.net
Little is known of the molecular regulation of human milk production because of limitations in
obtaining mammary tissue from lactating women. Our objectives were to evaluate whether …

牛催乳素受体(PRLR) 基因HinfⅠ 多态性与奶牛生产性能相关性研究

张佳兰, 昝林森, 申光磊 - 畜牧兽医学报, 2007 - xmsyxb.com
采用PCR-RFLP 方法检测了牛催乳素受体(PRLR) 基因intron 8 多态性. 结果表明:
中国荷斯坦牛, 加拿大荷斯坦和澳洲荷斯坦牛群体中Hinf Ⅰ 酶切后均有A 和B …

[HTML][HTML] Prolactin induces lipid synthesis of organ-cultured pigeon crops

XP Wan, P Xie, Z Bu, XT Zou, DQ Gong - Poultry science, 2019 - Elsevier
The objective of this research was to examine the effects of prolactin (PRL) on the lipid
synthesis of organ-cultured pigeon crops in vitro. In experiment 1, the histology, activities of …

From bench to bedside: future potential for the translation of prolactin inhibitors as breast cancer therapeutics

CV Clevenger, J Zheng, EM Jablonski… - Journal of mammary …, 2008 - Springer
A role for prolactin (PRL) in the pathogenesis of breast cancer has been confirmed at the
cellular level in vitro, with multiple transgenic and knockout models in vivo, and within …

Analysis of Brca1-deficient mouse mammary glands reveals reciprocal regulation of Brca1 and c-kit

CE Smart, A Wronski, JD French, SL Edwards… - Oncogene, 2011 - nature.com
Disruption of the breast cancer susceptibility gene Brca1 results in defective lobular-alveolar
development in the mammary gland and a predisposition to breast tumourigenesis in …