Stem cell therapy for spinal cord injury

L Huang, C Fu, F Xiong, C He, Q Wei - Cell transplantation, 2021 - journals.sagepub.com
Traumatic spinal cord injury (SCI) results in direct and indirect damage to neural tissues,
which results in motor and sensory dysfunction, dystonia, and pathological reflex that …

[HTML][HTML] Ambulation in dogs with absent pain perception after acute thoracolumbar spinal cord injury

MJ Lewis, ND Jeffery, NJ Olby… - Frontiers in veterinary …, 2020 - frontiersin.org
Acute thoracolumbar spinal cord injury (SCI) is common in dogs frequently secondary to
intervertebral disc herniation. Following severe injury, some dogs never regain sensory …

[HTML][HTML] Peripheral macrophage-derived exosomes promote repair after spinal cord injury by inducing local anti-inflammatory type microglial polarization via …

B Zhang, F Lin, J Dong, J Liu, Z Ding… - International journal of …, 2021 - ncbi.nlm.nih.gov
Abstract Treatment for spinal cord injury (SCI) remains a challenge worldwide, and
inflammation is a major cause of secondary injury after SCI. Peripheral macrophages (PMs) …

GDF‐11 Protects the Traumatically Injured Spinal Cord by Suppressing Pyroptosis and Necroptosis via TFE3‐Mediated Autophagy Augmentation

Y Xu, X Hu, F Li, H Zhang, J Lou… - Oxidative Medicine …, 2021 - Wiley Online Library
Spinal cord injury (SCI) refers to a major worldwide cause of accidental death and disability.
However, the complexity of the pathophysiological mechanism can result in less‐effective …

[HTML][HTML] The potential of gene therapies for spinal cord injury repair: a systematic review and meta-analysis of pre-clinical studies

CJ Cunningham, M Viskontas, K Janowicz… - Neural Regeneration …, 2023 - journals.lww.com
Currently, there is no cure for traumatic spinal cord injury but one therapeutic approach
showing promise is gene therapy. In this systematic review and meta-analysis, we aim to …

[HTML][HTML] Human menstrual blood-derived stem cells promote functional recovery in a rat spinal cord hemisection model

Q Wu, Q Wang, Z Li, X Li, J Zang, Z Wang, C Xu… - Cell death & …, 2018 - nature.com
Spinal cord injury (SCI) is associated with a dismal prognosis including severe voluntary
motor and sensory deficits in the presence of the current therapies, thus new and efficient …

[HTML][HTML] Effect and mechanism of human umbilical cord mesenchymal stem cells in treating allergic rhinitis in mice

X Kan, X Pan, J Zhao, J He, X Cai, R Pang, X Zhu… - Scientific reports, 2020 - nature.com
A model of allergic rhinitis (AR) in BALB/c mice was established and evaluated to provide
experimental subjects for further research. Preparation of human umbilical cord …

[HTML][HTML] Current status and future strategies to treat spinal cord injury with adult stem cells

SK Jeong, I Choi, SR Jeon - Journal of Korean …, 2020 - synapse.koreamed.org
Spinal cord injury (SCI) is one of the most devastating conditions and many SCI patients
suffer neurological sequelae. Stem cell therapies are expected to be beneficial for many …

Frizzled 1 and Wnt1 as new potential therapeutic targets in the traumatically injured spinal cord

P González, C González-Fernández… - Cellular and Molecular …, 2020 - Springer
Despite the experimental evidence pointing to a significant role of the Wnt family of proteins
in physiological and pathological rodent spinal cord functioning, its potential relevance in …

Growth factor gene-modified cells in spinal cord injury recovery: a systematic review

M Yousefifard, A Sarveazad, A Babahajian… - World neurosurgery, 2022 - Elsevier
Background Numerous preclinical studies have been performed in recent years on the
effects of the administration of growth factor gene-modified cells in spinal cord injury (SCI) …