SIRT7 promotes Hippo/YAP activation and cancer cell proliferation in hepatocellular carcinoma via suppressing MST1
Y Gu, C Ding, T Yu, B Liu, W Tang, Z Wang… - Cancer …, 2024 - Wiley Online Library
Abnormal activation of the oncogene YAP in the Hippo pathway is a major feature in liver
cancer and inactivation of MST1/2 has been shown to be responsible for the overactivation …
cancer and inactivation of MST1/2 has been shown to be responsible for the overactivation …
Cytoplasmic sirtuin 6 translocation mediated by p62 polyubiquitination plays a critical role in cadmium-induced kidney toxicity
KY So, BH Park, SH Oh - Cell Biology and Toxicology, 2021 - Springer
Abstract Sirtuin 6 (Sirt6) is important for maintaining kidney homeostasis and function. Cd
exposure increases the risk of developing kidney diseases. However, the role of Sirt6 in …
exposure increases the risk of developing kidney diseases. However, the role of Sirt6 in …
Interaction between RECQL4 and OGG1 promotes repair of oxidative base lesion 8-oxoG and is regulated by SIRT1 deacetylase
OGG1 initiated base excision repair (BER) is the major pathway for repair of oxidative DNA
base damage 8-oxoguanine (8-oxoG). Here, we report that RECQL4 DNA helicase, deficient …
base damage 8-oxoguanine (8-oxoG). Here, we report that RECQL4 DNA helicase, deficient …
[HTML][HTML] Sirt1 promotes the restoration of hepatic progenitor cell (HPC)-mediated liver fatty injury in NAFLD through activating the Wnt/β-catenin signal pathway
Q Li, Y Gong, Y Wang, B Liu, Y Chu, S Gui… - Frontiers in …, 2021 - frontiersin.org
Non-alcoholic fatty liver disease (NAFLD) has developed into the world's largest chronic
epidemic. In NAFLD, hepatic steatosis causes hepatocytes dysfunction and even apoptosis …
epidemic. In NAFLD, hepatic steatosis causes hepatocytes dysfunction and even apoptosis …
Can resveratrol modulate sirtuins in obesity and related diseases? A systematic review of randomized controlled trials
GM Fraiz, AR da Conceição… - European Journal of …, 2021 - Springer
Purpose Human sirtuins can be a powerful therapeutic target in preventing and treating
obesity and age-related diseases. Some dietary components can modulate sirtuins' activity …
obesity and age-related diseases. Some dietary components can modulate sirtuins' activity …
In vitro expression of NLRP inflammasome-induced active Caspase-1 expression in normal human epidermal keratinocytes (NHEK) by various exogenous threats and …
JV Gruber, R Holtz - Journal of inflammation research, 2019 - Taylor & Francis
Background The discovery of the nod-like receptor protein (NLRP) inflammasomes in 2002
has led to the rapid identification of these unique cellular proteins as key targets for studies …
has led to the rapid identification of these unique cellular proteins as key targets for studies …
[HTML][HTML] Recent advances in the development of histone deacylase SIRT2 inhibitors
W Yang, W Chen, H Su, R Li, C Song, Z Wang… - RSC advances, 2020 - pubs.rsc.org
Sirtuin 2 (SIRT2) is an important and special member of the atypical histone deacetylase
Sirtuin (SIRT) family. Due to its extensive catalytic effects, SIRT2 can regulate autophagy …
Sirtuin (SIRT) family. Due to its extensive catalytic effects, SIRT2 can regulate autophagy …
The yin and yang faces of the mitochondrial deacetylase sirtuin 3 in age-related disorders
Aging, the most important risk factor for many of the chronic diseases affecting Western
society, is associated with a decline in mitochondrial function and dynamics. Sirtuin 3 …
society, is associated with a decline in mitochondrial function and dynamics. Sirtuin 3 …
[HTML][HTML] SIRT6 enhances telomerase activity to protect against DNA damage and senescence in hypertrophic ligamentum flavum cells from lumbar spinal stenosis …
J Chen, Z Liu, H Wang, L Qian, Z Li, Q Song… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
Lumbar spinal stenosis (LSS) is a condition wherein patients exhibit age-related fibrosis,
elastin-to-collagen ratio reductions, and ligamentum flavum hypertrophy. This study was …
elastin-to-collagen ratio reductions, and ligamentum flavum hypertrophy. This study was …
Novel xanthone derivatives as potent sirtuin 2 inhibitors
G Mazur, K Pańczyk-Straszak, K Krysińska… - Bioorganic & Medicinal …, 2024 - Elsevier
Six amino derivatives of xanthone were obtained via chemical synthesis. Biochemical
studies revealed their SIRT2 inhibitory activity ranging from 48.5%(compound 4, 5-chloro-2 …
studies revealed their SIRT2 inhibitory activity ranging from 48.5%(compound 4, 5-chloro-2 …