Vitamin D has a well-known role in the calcium homeostasis associated with the
maintenance of healthy bones. It increases the efficiency of the intestinal absorption of …

Abstract The Klotho proteins, αKlotho and βKlotho, are essential components of endocrine
fibroblast growth factor (FGF) receptor complexes, as they are required for the high-affinity …

Bile acids are a large family of atypical steroids which exert their functions by binding to a
family of ubiquitous cell membrane and nuclear receptors. There are two main bile acid …

Loss of Klotho, an anti-aging protein, plays a critical role in the pathogenesis of chronic
kidney diseases. As Klotho is a large transmembrane protein, it is challenging to harness it …

1, 25-Dihydroxvitamin D3 [1, 25 (OH) 2D3] is the hormonally active form of vitamin D. The
genomic mechanism of 1, 25 (OH) 2D3 action involves the direct binding of the 1, 25 (OH) …

Cisplatin is a widely used chemotherapeutic agent used to treat solid tumours, such as
ovarian, head and neck, and testicular germ cell. A known complication of cisplatin …

The ageing suppressor α-klotho binds to the fibroblast growth factor receptor (FGFR). This
commits FGFR to respond to FGF23, a key hormone in the regulation of mineral ion and …

The signaling component of the mammalian Fibroblast Growth Factor (FGF) family is
comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF …

Klotho has been recognized as a gene involved in the aging process in mammals for over
30 years, where it regulates phosphate homeostasis and the activity of members of the …

Osteoporosis is characterized by low bone mass and microarchitecture deterioration of bone
tissue, leading to enhanced bone fragility and consequent increase in fracture risk. Evidence …