Iron is an essential trace element for the human body, and its deficiency or excess can
induce a variety of biological processes. Plenty of evidences have shown that iron …

Ferroptosis is an iron-dependent programmed cell death pattern that is characterized by iron
overload, reactive oxygen species (ROS) accumulation and lipid peroxidation. Growing …

Acute myeloid leukemia (AML) is one of the most aggressive hematological malignancies
with a low 5-year survival rate and high rate of relapse. Developing more efficient therapies …

Background: The incidence of clear cell renal cell carcinoma (ccRCC) is increasing
worldwide, contributing to 70–85% of kidney cancer cases. Ferroptosis is a novel type of …

Background Tumor immunological heterogeneity potentially influences the prognostic
disparities among patients with clear cell renal cell carcinoma (ccRCC); however, there is a …

Urinary malignancies refer to a series of malignant tumors that occur in the urinary system
and mainly include kidney, bladder, and prostate cancers. Although local or systemic …

Liquid biopsy is a noninvasive technique that can provide valuable information for disease
characterization by using biofluids as a source of biomarkers. Proteins found in biofluids can …

Abstract Nuclear receptor coactive 4 (NCOA4), which functions as a selective cargo
receptor, is a critical regulator of the particularly autophagic degradation of ferritin, a process …

Background Despite numerous treatments available, clear cell renal cell carcinoma (ccRCC)
remains a deadly and invasive cancer. Anoikis-related genes (ARGs) are essential …

Tumor immune microenvironment constituents, such as CD8+ T cells, have emerged as
crucial focal points for cancer immunotherapy. Given the absence of reliable biomarkers for …