Tobacco use is a major public health problem worldwide. Tobacco-related cancers cause
millions of deaths annually. Although several tobacco agents play a role in the development …

Exogenous and endogenous sources of chemical species can react, directly or after
metabolic activation, with DNA to yield DNA adducts. If not repaired, DNA adducts may …

Oral cancer is a major public health burden worldwide. The lack of biomarkers for early
diagnosis has increased the difficulty in managing this disease. Recent studies have …

Liquid chromatography coupled with mass spectrometry (LC-MS) is the method of choice for
analysis of covalent modification of DNA. DNA adductomics is an extension of this approach …

A high-resolution/accurate-mass DNA adductomic approach was developed to investigate
anticipated and unknown DNA adducts induced by DNA alkylating agents in biological …

Tobacco smoke delivers a complex mixture of hazardous and potentially hazardous
chemicals. Some of these may induce the formation of DNA mutations, which increases the …

The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a
potent pulmonary carcinogen in laboratory animals. It is classified as a Group 1 human …

The tobacco-specific nitrosamines N '-nitrosonornicotine (NNN, 1) and 4-
(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK, 2) are potent carcinogens in rodents …

4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK, 1) and its metabolite, 4-
(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL, 2) are both potent pulmonary …

4‐(Methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanone (NNK) and N′‐nitrosonornicotine (NNN)
are tobacco‐specific nitrosamines present in tobacco products and smoke. Both compounds …