Longer human lives have led to a global burden of late-life disease. However, some older
people experience little ill health, a trait that should be extended to the general population …

Aging constitutes the key risk factor for age‐related diseases such as cancer and
cardiovascular and neurodegenerative disorders. Human longevity and healthy aging are …

Between the 1930s and 50s, evolutionary biologists developed a successful theory of why
organisms age, firmly rooted in population genetic principles. By the 1980s the evolution of …

The C. elegans insulin/IGF-1 signaling (IIS) pathway connects nutrient levels to metabolism,
growth, development, longevity, and behavior. This fundamental pathway is regulated by …

Secretion of growth hormone (GH), and consequently that of insulin-like growth factor 1 (IGF-
1), declines over time until only low levels can be detected in individuals aged≥ 60 years …

Discovering the biological basis of aging is one of the greatest remaining challenges for
science. Work on the biology of aging has discovered a range of interventions and pathways …

A NEW YORK TIMES BESTSELLER “Brilliant and enthralling.”​—The Wall Street Journal A
paradigm-shifting book from an acclaimed Harvard Medical School scientist and one of …

In contrast to the programmed nature of development, it is still a matter of debate whether
aging is an adaptive and regulated process, or merely a consequence arising from a …

Aging drives progressive loss of the ability of tissues to recover from stress, partly through
loss of somatic stem cell function and increased senescent burden. We demonstrate that …

The insulin-like growth factors (IGF-I and IGF-II) and their receptors are widely expressed in
nervous tissue from early embryonic life. They also cross the blood brain barriers by active …