Mucoadhesion can be defined as a state in which two components, of which one is of
biological origin, are held together for extended periods of time by the help of interfacial …

Preclinical studies suggest that the brain corticotropin-releasing factor (CRF) systems
mediate anxiety-like behavioural and somatic responses through actions at the CRF1 …

The present study deals with the development and characterization of self-nanoemulsifying
drug delivery system (SNEDDS) to improve the oral bioavailability of poorly soluble third …

Nowadays, heterocyclic compounds act as a scaffold and are the backbone of medicinal
chemistry. Among all of the heterocyclic scaffolds, 1, 4-Dihydropyridine (1, 4-DHP) is one of …

Lercanidipine is a lipophilic, dihydropyridine calcium antagonist with a long receptor half-
life. Its slow onset of action helps to avoid reflex tachycardia associated with other …

Calcium channel blockers (CCBs), which include both dihydropyridines such as nifedipine
and amlodipine and non‐dihydropyridines (verapamil and diltiazem), are among the most …

Increased levels of metalloproteinase (MMP)-9 have been shown in hypertensive patients.
Lercanidipine is a calcium channel blocker with antioxidant actions. We examined whether …

A novel strategy for the ESI‐MS monitoring of reaction solutions involving the alternate use
of permanently charge‐tagged reagents has been used for comprehensive mass …

Background: It has been previously demonstrated that dihydropyridine calcium channel
blockers may possess antioxidant properties and might improve vascular structure …

Methods The matrix type TDDS of LRDP were prepared by solvent evaporation technique.
Formulations A1, A2, A3, A4, A5 and A6 were composed of Eudragit RL100 (ERL) and …