The discovery of the role of the RAS/RAF/MEK/ERK pathway in melanomagenesis and its
progression have opened a new era in the treatment of this tumor. Vemurafenib was the first …

Cancer patients frequently use complementary medicine. Curcumin (CUR) and its derivates
(from the extract of Curcuma longa L.) represent some of the most frequently used ones …

Colorectal cancer (CRC) is still one of the deadliest cancer-related diseases. About 10% of
CRC patients are characterized by a mutation in the B-Raf proto-oncogene serine/threonine …

An overactivation of hepatocyte growth factor (HGF)/mesenchymal-epithelial transition factor
(MET) axis promotes tumorigenesis and tumor progression in various cancer types …

The ability to selectively eradicate oncogene-addicted tumors while reducing systemic
toxicity has endeared targeted therapies as a treatment strategy. Nevertheless, development …

Background cAMP responsive element binding protein 5 (CREB5) is a transcriptional
activator in eukaryotic cells that can regulate gene expression. Previously, we found that …

DNA double-strand breaks (DSB) are among the most harmful DNA lesions induced by
ionizing radiation (IR). Although the induction and repair of radiation-induced DSB is well …

Targeting the epidermal growth factor receptor (EGFR) either alone or in combination with
chemotherapy in patients with RAS wild type metastatic colorectal cancer (mCRC) has …

In 2023, colorectal cancer (CRC) is the third most diagnosed malignancy and the third
leading cause of cancer death worldwide. At the time of the initial visit, 20% of patients …

The human epidermal growth factor receptor (HER, ErbB) family has four members,
epidermal growth factor receptor (EGFR), HER2, HER3, and HER4. Although distinct in …