Tumor suppressor genes cooperate with each other in tumors. Three important tumor
suppressor proteins, retinoblastoma (Rb), p53, phosphatase, and tensin homolog deleted …

Proteasome-mediated degradation is a common mechanism by which cells renew their
intracellular proteins and maintain protein homeostasis. In this process, the E3 ubiquitin …

INTRODUCTION Inhibition of oncogenic proteins represents a mainstay approach for cancer
therapeutic development. By contrast, pharmacological modulation of tumor suppressor …

Thousands of lncRNAs have been identified but few have been functionally characterized in
triple negative breast cancer (TNBC). LINC00152 was known as cytoskeleton regulator RNA …

Background & Aims There has not been a broad analysis of the combined effects of altered
activities of microRNAs (miRNAs) in pancreatic ductal adenocarcinoma (PDAC) cells, and it …

Ubiquitination plays a crucial role in regulating proteins post-translationally. The focus of this
review is on NEDD4, the founding member of the NEDD4 family of ubiquitin ligases that is …

Tumorigenesis, tumor growth, and prognosis are highly related to gene alterations and post-
translational modifications (PTMs). Ubiquitination is a critical PTM that governs practically all …

Advances in the generation and interpretation of proteomics data have spurred a transition
from focusing on protein identification to functional analysis. Here we review recent …

J. Neurochem.(2011) 119, 27–39. Abstract α‐Amino‐3‐hydroxy‐5‐methyl‐isoxazole‐4‐
propionic acid receptors (AMPARs) are the primary mediators of excitatory synaptic …

The human genome encodes several hundred E3 ubiquitin ligases containing RING
domains, and around 28 containing HECT domains. These enzymes catalyze the transfer of …