Neonatal cholestasis: emerging molecular diagnostics and potential novel therapeutics

AG Feldman, RJ Sokol - Nature reviews Gastroenterology & hepatology, 2019 - nature.com
Neonatal cholestasis is a group of rare disorders of impaired bile flow characterized by
conjugated hyperbilirubinaemia in the newborn and young infant. Neonatal cholestasis is …

Recent developments in diagnostics and treatment of neonatal cholestasis

AG Feldman, RJ Sokol - Seminars in pediatric surgery, 2020 - Elsevier
Neonatal cholestasis is characterized by conjugated hyperbilirubinemia in the newborn and
young infant and is a sign common to over 100 hepatobiliary and/or metabolic disorders. A …

MicroRNA-221/222 family counteracts myocardial fibrosis in pressure overload–induced heart failure

R Verjans, T Peters, FJ Beaumont, R van Leeuwen… - …, 2018 - Am Heart Assoc
Pressure overload causes cardiac fibroblast activation and transdifferentiation, leading to
increased interstitial fibrosis formation and subsequently myocardial stiffness, diastolic and …

The tumor microenvironment controls drug sensitivity

A Östman - Nature medicine, 2012 - nature.com
A better understanding of mechanisms involved in regulation of drug sensitivity is crucial for
improved cancer treatment. New studies show that cells of the tumor microenvironment …

Shear wave elastography helps differentiate biliary atresia from other neonatal/infantile liver diseases

JR Leschied, JR Dillman, J Bilhartz, A Heider… - Pediatric …, 2015 - Springer
Background Biliary atresia is a rapidly progressive liver disease necessitating prompt
diagnosis and surgical intervention, so it must be promptly distinguished from other …

Diagnostic values of plasma matrix metalloproteinase-7, interleukin-8, and gamma-glutamyl transferase in biliary atresia

B Wu, Y Zhou, X Tian, W Cai, Y Xiao - European journal of pediatrics, 2022 - Springer
Biliary atresia (BA) is a severe cholestatic liver disease in children featuring cholestasis and
liver fibrosis. The early diagnosis of BA is still challenging. This study aimed to evaluate the …

Assessment of native liver fibrosis using ultrasound elastography and serological fibrosis indices in children with biliary atresia after the Kasai procedure

J Hwang, HM Yoon, KM Kim, SH Oh… - Acta …, 2021 - journals.sagepub.com
Background Validated non-invasive examinations are necessary to monitor liver fibrosis in
children with biliary atresia (BA) after the Kasai procedure. Purpose To evaluate the …

Interleukin‐8: a critical chemokine in biliary atresia

R Dong, S Zheng - Journal of gastroenterology and hepatology, 2015 - Wiley Online Library
Biliary atresia (BA) is characterized by periductular inflammation and fibrosis and is
associated with the progressive obliteration of the bile ducts. The induction and …

Utility of shear wave elastography for differentiating biliary atresia from infantile hepatitis syndrome

X Wang, L Qian, L Jia, R Bellah… - … of Ultrasound in …, 2016 - Wiley Online Library
Objectives The purpose of this study was to investigate the potential utility of shear wave
elastography (SWE) for diagnosis of biliary atresia and for differentiating biliary atresia from …

Transient elastography and sonography for prediction of liver fibrosis in infants with biliary atresia

NY Shin, MJ Kim, MJ Lee, SJ Han… - … of Ultrasound in …, 2014 - Wiley Online Library
Objectives The purpose of this study was to assess the diagnostic performance of transient
elastography and sonography for noninvasive evaluation of liver fibrosis in infants with …