RhoA is a ubiquitously expressed cytoplasmic protein that belongs to the family of small
GTPases. RhoA acts as a molecular switch that is activated in response to binding of …

Cell motility is essential for life and development. Unfortunately, cell migration is also linked
to several pathological processes, such as cancer metastasis. Cells' ability to migrate relies …

Abstract Background Activation of CXCL12/CXCR4 axis has been found to be associated
with invasion and metastasis in many cancers. However, the underlying mechanism remains …

Introduction The cytokine release syndrome (CRS) of COVID-19 is associated with the
development of critical illness requiring multi-organ support. Further research is required to …

Dynamic and heterogeneous interaction between tumor cells and the surrounding
microenvironment fuels the occurrence, progression, invasion, and metastasis of solid …

Myoblast fusion into myotubes is one of the crucial steps of skeletal muscle development
(myogenesis). The fusion is preceded by specification of a myogenic lineage (mesodermal …

RHO GTPases are a subfamily of the RAS superfamily of proteins, which are highly
conserved in eukaryotic species and have important biological functions, including actin …

Wnt signaling plays a major role in regulating cell proliferation and differentiation. The Wnt
ligands are a family of 19 secreted glycoproteins that mediate their signaling effects via …

In response to repulsive cues, axonal growth cones can quickly retract. This requires the
prompt activity of contractile actomyosin, which is formed by the non-muscle myosin II (NMII) …

Ras homolog (Rho)-associated kinases (ROCKs) belong to the serine-threonine kinase
family, which plays a pivotal role in regulating the damage, survival, axon guidance, and …