Non-canonical WNT signalling in cardiovascular disease: mechanisms and therapeutic implications

I Akoumianakis, M Polkinghorne… - Nature Reviews …, 2022 - nature.com
WNT signalling comprises a diverse spectrum of receptor-mediated pathways activated by a
large family of WNT ligands and influencing fundamental biological processes. WNT …

WNT signaling in melanoma

A Gajos-Michniewicz, M Czyz - International journal of molecular sciences, 2020 - mdpi.com
WNT-signaling controls important cellular processes throughout embryonic development
and adult life, so any deregulation of this signaling can result in a wide range of pathologies …

Molecular mechanisms of adipogenesis: the anti-adipogenic role of AMP-activated protein kinase

B Ahmad, CJ Serpell, IL Fong… - Frontiers in molecular …, 2020 - frontiersin.org
Obesity is now a widespread disorder, and its prevalence has become a critical concern
worldwide, due to its association with common co-morbidities like cancer, cardiovascular …

Association between obesity, inflammation and insulin resistance: Insights into signaling pathways and therapeutic interventions

SS Garg, K Kushwaha, R Dubey, J Gupta - Diabetes research and clinical …, 2023 - Elsevier
Obesity, a metabolic disorder, is becoming a worldwide epidemic that predominantly
increases the risk for various diseases including metabolic inflammation, insulin resistance …

Running against the Wnt: How Wnt/β-catenin suppresses adipogenesis

TJJ De Winter, R Nusse - Frontiers in cell and developmental biology, 2021 - frontiersin.org
Mesenchymal stem cells (MSCs) give rise to adipocytes, osteocytes, and chondrocytes and
reside in various tissues, including bone marrow and adipose tissue. The differentiation …

Inflammation and Wnt signaling: target for immunomodulatory therapy?

I Jridi, K Canté-Barrett, K Pike-Overzet… - Frontiers in cell and …, 2021 - frontiersin.org
Wnt proteins comprise a large family of highly conserved glycoproteins known for their role
in development, cell fate specification, tissue regeneration, and tissue homeostasis …

The WNT signaling pathways in wound healing and fibrosis

O Burgy, M Königshoff - Matrix Biology, 2018 - Elsevier
The WNT signaling pathways are major regulators of organ development. Ample research
over the past few decades revealed that these pathways are critically involved in adult tissue …

Wnt signaling mediates TLR pathway and promote unrestrained adipogenesis and metaflammation: therapeutic targets for obesity and type 2 diabetes

K Aamir, HU Khan, G Sethi, MA Hossain… - Pharmacological …, 2020 - Elsevier
Diabesity is the combination of type 2 diabetes and obesity characterized by chronic low-
grade inflammation. The Wnt signaling act as an evolutionary pathway playing crucial role in …

Targeting breast cancer stem cells through retinoids: a new hope for treatment

N Jan, S Sofi, H Qayoom, BU Haq, A Shabir… - Critical Reviews in …, 2023 - Elsevier
Breast cancer is a complex and diverse disease accounting for nearly 30% of all cancers
diagnosed in females. But unfortunately, patients develop resistance to the existing …

Cinnamon extract combined with high-intensity endurance training alleviates metabolic syndrome via non-canonical WNT signaling

E Fayaz, A Damirchi, N Zebardast, P Babaei - Nutrition, 2019 - Elsevier
Objectives The incidence of metabolic syndrome (MetS) in menopausal women is one of the
main health care concerns. MetS clusters are related to an imbalance in pro-and anti …