[HTML][HTML] Management of statin intolerance in 2018: still more questions than answers
PP Toth, AM Patti, RV Giglio, D Nikolic… - American Journal of …, 2018 - Springer
Statin therapy is generally well tolerated and very effective in the prevention and treatment of
cardiovascular disease, regardless of cholesterol levels; however, it can be associated with …
cardiovascular disease, regardless of cholesterol levels; however, it can be associated with …
Virtual screening techniques in drug discovery: review and recent applications
SFL da Silva Rocha, CG Olanda… - Current topics in …, 2019 - ingentaconnect.com
The discovery of bioactive molecules is an expensive and time-consuming process and new
strategies are continuously searched for in order to optimize this process. Virtual Screening …
strategies are continuously searched for in order to optimize this process. Virtual Screening …
Mendelian randomization study of PCSK9 and HMG-CoA reductase inhibition and cognitive function
DB Rosoff, AS Bell, J Jung, J Wagner… - Journal of the American …, 2022 - jacc.org
Background Lipid-lowering therapy with statins and proprotein convertase subtilisin/kexin
type 9 (PCSK9) inhibition are effective strategies in reducing cardiovascular disease risk; …
type 9 (PCSK9) inhibition are effective strategies in reducing cardiovascular disease risk; …
Proprotein convertase subtilisin/kexin type 9 (PCSK9) in the central nervous system
AS Bell, J Wagner, DB Rosoff, FW Lohoff - Neuroscience & Biobehavioral …, 2023 - Elsevier
The gene encoding proprotein convertase subtilisin/kexin type 9 (PCSK9) and its protein
product have been widely studied for their role in cholesterol and lipid metabolism. PCSK9 …
product have been widely studied for their role in cholesterol and lipid metabolism. PCSK9 …
PCSK9 inhibitors for treating hypercholesterolemia
A Pasta, AL Cremonini, L Pisciotta… - Expert opinion on …, 2020 - Taylor & Francis
Introduction: Scientific evidence on subjects treated with statin or other lipid-lowering
treatments has established that treatments aiming to lower low-density lipoprotein …
treatments has established that treatments aiming to lower low-density lipoprotein …
Novel strategies to target proprotein convertase subtilisin kexin 9: beyond monoclonal antibodies
Since the discovery of the role of proprotein convertase subtilisin kexin 9 (PCSK9) in the
regulation of low-density lipoprotein cholesterol (LDL-C) in 2003, a paradigm shift in the …
regulation of low-density lipoprotein cholesterol (LDL-C) in 2003, a paradigm shift in the …
Meta‐analysis of clinical outcomes of PCSK9 modulators in patients with established ASCVD
AH Talasaz, AC Ho, F Bhatty, RA Koenig… - … : The Journal of …, 2021 - Wiley Online Library
The advent of monoclonal antibodies targeting proprotein convertase subtilisin/kexin type 9
(PCSK9) ushered in a new era of dyslipidemia pharmacotherapy. The first two antibodies …
(PCSK9) ushered in a new era of dyslipidemia pharmacotherapy. The first two antibodies …
Effect of access to prescribed PCSK9 inhibitors on cardiovascular outcomes
KD Myers, N Farboodi, M Mwamburi… - … Quality and Outcomes, 2019 - Am Heart Assoc
Background: Atherosclerotic cardiovascular disease remains a major cause of death and
disability, especially for high-risk familial hypercholesterolemia individuals. PCSK9i …
disability, especially for high-risk familial hypercholesterolemia individuals. PCSK9i …
PCSK9 inhibitors in lipid management of patients with diabetes mellitus and high cardiovascular risk: a review
Y Handelsman, NE Lepor - Journal of the American Heart …, 2018 - Am Heart Assoc
(LDL-C) are well established to be associated with the development of atherosclerotic
cardiovascular disease (ASCVD), defined as acute coronary syndrome, a history of …
cardiovascular disease (ASCVD), defined as acute coronary syndrome, a history of …
[HTML][HTML] The effect of PCSK9 inhibition on the stabilization of atherosclerotic plaque determined by biochemical and diagnostic imaging methods
M Basiak, M Hachula, M Kosowski, G Machnik… - Molecules, 2023 - mdpi.com
Atherosclerosis is a multifactorial, progressive, chronic inflammatory disease. Ultrasound
and magnetic resonance imaging are the most accurate predictors of atherosclerotic plaque …
and magnetic resonance imaging are the most accurate predictors of atherosclerotic plaque …