If assessed by a number of criteria for cancer predisposition, Down's syndrome (DS) should
be an overwhelmingly cancer-prone condition. Although childhood leukaemias occur more …

Newborns and children with Down syndrome (DS) often present with congenital transient
leukemia and have an increased risk of acute myeloid leukemia and acute lymphoblastic …

We characterized the mutational status of the FLT3 tyrosine kinase domain (FLT3-TLD) in
3082 patients with newly diagnosed AML. FLT3-TKD mutations were detected in 147 of …

Practical and clinically focused, Abeloff's Clinical Oncology is a trusted medical reference
book designed to capture the latest scientific discoveries and their implications for cancer …

Balanced chromosomal rearrangements define distinct entities in acute myeloid leukemia
(AML). Here, we present 13 AML cases with t (8; 16)(p11; p13) with observed low incidence …

Geographic heterogeneity of cytogenetic patterns in hematological malignancies has been
reported earlier, but few systematic studies of cytogenetic abnormalities in acute myeloid …

Blood malignancies arise from the dysregulation of haematopoiesis. The type of blood cell
and the specific order of oncogenic events initiating abnormal growth ultimately determine …

The purpose of the present work was to determine the incidence and clinical implications of
somatic EZH2 mutations in 714 patients with de novo acute myelogenous leukemia by …

Background: The diagnosis of AML with monocytic differentiation is limited by the lack of
highly sensitive and specific monocytic markers. Immunoglobulin‐like transcript 3 (ILT3) is …

BACKGROUND: Cigarette smoking is an established risk factor for adult myeloid leukemia,
particularly acute myeloid leukemia (AML), but less is known about the nature of this …