Individuals with Down syndrome (DS) are at elevated risk for acute leukemia, whereas solid
tumors are uncommon, and most types, including breast cancers, have significantly lower …

Objectives: Acquired trisomy 21 is one of the most common numerical abnormalities in acute
myeloid leukemia (AML), myelodysplastic syndrome (MDS), myeloproliferative neoplasms …

Background Chromosomal analysis is essential for the diagnosis and risk stratification of all
leukemia patients. Not surprisingly, racial differences in chromosomal aberrations (CA) in …

Background We analyzed the cytogenetic characteristics of a representative population of
young adults with de novo acute myéloblastic leukemia (AML) treated in a single center …

Acute myeloid leukemias were previously known as a single disease, they are a
heterogeneous group of diseases with different morphological characteristics and several …

Dysregulation of biological processes in normal cells can lead to the abnormal growth of
tumours. Oncogenesis requires the acquisition of advantageous mutations to expand in a …

Single genetic aberrations are often not sufficient to cause the onset of cancer, but they
contribute to the transformation of normal cells into cells with neoplastic phenotypes and as …

The clinical implications of cohesin gene complex mutation in acute myeloid leukemia (AML)
are not well characterized. In the present study, a cohort of 152 de novo unselected adult …