[HTML][HTML] Innate immunity: the first line of defense against SARS-CoV-2
MS Diamond, TD Kanneganti - Nature immunology, 2022 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute
respiratory syndrome coronavirus (SARS-CoV)-2, continues to cause substantial morbidity …
respiratory syndrome coronavirus (SARS-CoV)-2, continues to cause substantial morbidity …
[HTML][HTML] Devilishly radical NETwork in COVID-19: Oxidative stress, neutrophil extracellular traps (NETs), and T cell suppression
G Schönrich, MJ Raftery, Y Samstag - Advances in biological regulation, 2020 - Elsevier
Abstract Pandemic coronavirus disease 2019 (COVID-19) is caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) and poses an unprecedented challenge …
respiratory syndrome coronavirus 2 (SARS-CoV-2) and poses an unprecedented challenge …
ZBP1-dependent inflammatory cell death, PANoptosis, and cytokine storm disrupt IFN therapeutic efficacy during coronavirus infection
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for
coronavirus disease 2019 (COVID-19), continues to cause substantial morbidity and …
coronavirus disease 2019 (COVID-19), continues to cause substantial morbidity and …
[PDF][PDF] Shared and distinct functions of type I and type III interferons
Type I interferons (IFNs)(IFN-α, IFN-β) and type III IFNs (IFN-λ) share many properties,
including induction by viral infection, activation of shared signaling pathways, and …
including induction by viral infection, activation of shared signaling pathways, and …
[HTML][HTML] Inhibition of SARS–CoV-2 by type I and type III interferons
U Felgenhauer, A Schoen, HH Gad, R Hartmann… - Journal of Biological …, 2020 - ASBMB
The recently emerged severe acute respiratory syndrome coronavirus-2 (SARS–CoV-2) is
the causative agent of the devastating COVID-19 lung disease pandemic. Here, we tested …
the causative agent of the devastating COVID-19 lung disease pandemic. Here, we tested …
Interferon target-gene expression and epigenomic signatures in health and disease
Multiple type I interferons and interferon-γ (IFN-γ) are expressed under physiological
conditions and are increased by stress and infections, and in autoinflammatory and …
conditions and are increased by stress and infections, and in autoinflammatory and …
[HTML][HTML] Interferon-gamma at the crossroads of tumor immune surveillance or evasion
F Castro, AP Cardoso, RM Gonçalves, K Serre… - Frontiers in …, 2018 - frontiersin.org
Interferon-gamma (IFN-γ) is a pleiotropic molecule with associated antiproliferative, pro-
apoptotic and antitumor mechanisms. This effector cytokine, often considered as a major …
apoptotic and antitumor mechanisms. This effector cytokine, often considered as a major …
Type I and III interferons disrupt lung epithelial repair during recovery from viral infection
J Major, S Crotta, M Llorian, TM McCabe, HH Gad… - Science, 2020 - science.org
Excessive cytokine signaling frequently exacerbates lung tissue damage during respiratory
viral infection. Type I (IFN-α and IFN-β) and III (IFN-λ) interferons are host-produced antiviral …
viral infection. Type I (IFN-α and IFN-β) and III (IFN-λ) interferons are host-produced antiviral …
[HTML][HTML] Host-directed therapies for bacterial and viral infections
SHE Kaufmann, A Dorhoi, RS Hotchkiss… - Nature reviews Drug …, 2018 - nature.com
Despite the recent increase in the development of antivirals and antibiotics, antimicrobial
resistance and the lack of broad-spectrum virus-targeting drugs are still important issues and …
resistance and the lack of broad-spectrum virus-targeting drugs are still important issues and …
[HTML][HTML] Novel insights into immune systems of bats
In recent years, viruses similar to those that cause serious disease in humans and other
mammals have been detected in apparently healthy bats. These include filoviruses …
mammals have been detected in apparently healthy bats. These include filoviruses …