Of wide interest for health is the relation existing between depression, a very common
psychological illness, accompanied by anxiety and reduced ability to concentrate, and adult …

Recent findings have established a connection between inflammation and major depression
and specifically the role of the hypothalamic–pituitary–adrenal (HPA) axis in depression …

Major depressive disorder is a common and disabling illness that leads to significant
reductions in quality of life and considerable cost to society. Despite numerous advances in …

A mouse model of depression has been recently developed by exogenous corticosterone
(CORT) administration, which has shown to mimic HPA-axis induced depression-like state in …

Objective To estimate the minimum clinically important difference (MCID) for several pain
measures obtained from the Brief Pain Inventory (BPI) for patients with fibromyalgia …

Background Although antidepressants are often a first‐line treatment for adults with
moderate to severe depression, many people do not respond adequately to medication, and …

As the population ages, spine-related pain is increasingly common in older adults. While
medications play an important role in pain management, their use has limitations in geriatric …

Both major depressive disorder and the anxiety disorders are major causes of disability and
markedly contribute to a significant global burden of the disease worldwide. In part because …

Patients with major depression often report pain. In this article, we review the current
literature regarding the prevalence and consequences, as well as the pathophysiology, of …

Abstract Introduction: Patient-reported outcomes (PROs) are of increasing importance in
clinical medicine. However, their evaluation by classic psychometric methods carries …