Traumatic brain injury and Alzheimer's disease: the cerebrovascular link

J Ramos-Cejudo, T Wisniewski, C Marmar… - …, 2018 - thelancet.com
Traumatic brain injury (TBI) and Alzheimer's disease (AD) are devastating neurological
disorders, whose complex relationship is not completely understood. Cerebrovascular …

The role of the posterior cingulate cortex in cognition and disease

R Leech, DJ Sharp - Brain, 2014 - academic.oup.com
The posterior cingulate cortex is a highly connected and metabolically active brain region.
Recent studies suggest it has an important cognitive role, although there is no consensus …

Axonal marker neurofilament light predicts long-term outcomes and progressive neurodegeneration after traumatic brain injury

NSN Graham, KA Zimmerman, F Moro… - Science translational …, 2021 - science.org
Axonal injury is a key determinant of long-term outcomes after traumatic brain injury (TBI) but
has been difficult to measure clinically. Fluid biomarker assays can now sensitively quantify …

Chronic impact of traumatic brain injury on outcome and quality of life: a narrative review

N Stocchetti, ER Zanier - Critical Care, 2016 - Springer
Traditionally seen as a sudden, brutal event with short-term impairment, traumatic brain
injury (TBI) may cause persistent, sometimes life-long, consequences. While mortality after …

Serum neurofilament light as a biomarker for mild traumatic brain injury in contact sports

P Shahim, H Zetterberg, Y Tegner, K Blennow - Neurology, 2017 - AAN Enterprises
Objective: To evaluate whether the axonal protein neurofilament light (NFL) in serum is a
sensitive biomarker to detect subtle brain injury or concussion in contact sports athletes …

Network dysfunction after traumatic brain injury

DJ Sharp, G Scott, R Leech - Nature Reviews Neurology, 2014 - nature.com
Diffuse axonal injury after traumatic brain injury (TBI) produces neurological impairment by
disconnecting brain networks. This structural damage can be mapped using diffusion MRI …

Prediction of brain age suggests accelerated atrophy after traumatic brain injury

JH Cole, R Leech, DJ Sharp… - Annals of …, 2015 - Wiley Online Library
Objective The long‐term effects of traumatic brain injury (TBI) can resemble observed in
normal ageing, suggesting that TBI may accelerate the ageing process. We investigate this …

Recovery of consciousness and functional outcome in moderate and severe traumatic brain injury

RG Kowalski, FM Hammond, AH Weintraub… - JAMA …, 2021 - jamanetwork.com
Importance Traumatic brain injury (TBI) leads to 2.9 million visits to US emergency
departments annually and frequently involves a disorder of consciousness (DOC). Early …

Cognitive network neuroscience

JD Medaglia, ME Lynall, DS Bassett - Journal of cognitive …, 2015 - direct.mit.edu
Network science provides theoretical, computational, and empirical tools that can be used to
understand the structure and function of the human brain in novel ways using simple …

Inflammation after trauma: microglial activation and traumatic brain injury

AF Ramlackhansingh, DJ Brooks… - Annals of …, 2011 - Wiley Online Library
Objective: Patient outcome after traumatic brain injury (TBI) is highly variable. The
underlying pathophysiology of this is poorly understood, but inflammation is potentially an …