The toxicology of heparin reversal with protamine: past, present and future

E Sokolowska, B Kalaska, J Miklosz… - Expert opinion on drug …, 2016 - Taylor & Francis
Introduction: Unfractionated heparin is a strongly anionic anticoagulant used extensively in
medicine to prevent blood clotting. In the case of an emergency bleeding in response to …

Reevaluation of lock solutions for Central venous catheters in hemodialysis: a narrative review

Y Wang, X Sun - Renal Failure, 2022 - Taylor & Francis
Background A significant proportion of incident and prevalent hemodialysis patients have
central venous catheters for vascular access. No consensus is available on the prevention of …

Porous polymers as universal reversal agents for heparin anticoagulants through an inclusion–sequestration mechanism

F Lin, SB Yu, YY Liu, CZ Liu, S Lu, J Cao… - Advanced …, 2022 - Wiley Online Library
Heparins are widely used anticoagulants for surgical procedures and extracorporeal
therapies. However, all of them have bleeding risks. Protamine sulfate, the only clinically …

Blood-incompatibility in haemodialysis: alleviating inflammation and effects of coagulation

SK Bowry, F Kircelli, R Himmele… - Clinical Kidney …, 2021 - academic.oup.com
Blood-incompatibility is an inevitability of all blood-contacting device applications and
therapies, including haemodialysis (HD). Blood leaving the environment of blood vessels …

How to ensure patency of the extracorporeal circuit in hemodialysis: global perspectives

A Santos, A Vega, A Davenport - Seminars in Nephrology, 2024 - Elsevier
An adequate knowledge of anticoagulants used to prevent clotting in the extracorporeal
circuit is crucial to provide optimal hemodialysis. Drugs can potentially prevent …

Multitargeted interventions to reduce dialysis-induced systemic stress

B Canaud, MP Stephens, M Nikam, M Etter… - Clinical Kidney …, 2021 - academic.oup.com
Hemodialysis (HD) is a life-sustaining therapy as well as an intermittent and repetitive stress
condition for the patient. In ridding the blood of unwanted substances and excess fluid from …

Anticoagulation in chronic hemodialysis: progress toward an optimal approach

M Kessler, F Moureau, P Nguyen - Seminars in Dialysis, 2015 - Wiley Online Library
Appropriate anticoagulation for hemodialysis (HD) requires a subtle balance between under‐
and over‐heparinization to prevent extracorporeal circuit (ECC) clotting and bleeding …

A highly efficient and selective optical detection method for Heparin that works in 100% human serum

SP Pandey, P Jha, PK Singh - Sensors and Actuators B: Chemical, 2022 - Elsevier
Sensing Heparin in 100% serum matrix is a challenging task and is rarely reported in
literature. Herein, we present a tetracationic porphyrin based probe that detects Heparin in …

Affinity-based design of a synthetic universal reversal agent for heparin anticoagulants

RA Shenoi, MT Kalathottukaren, RJ Travers… - Science translational …, 2014 - science.org
Heparin-based anticoagulant drugs have been widely used for the prevention of blood
clotting during surgical procedures and for the treatment of thromboembolic events …

Caltrop-like Small-Molecule Antidotes That Neutralize Unfractionated Heparin and Low-Molecular-Weight Heparin In Vivo

Y Zong, Z Lei, SB Yu, LY Zhang, Y Wu… - Journal of Medicinal …, 2024 - ACS Publications
Unfractionated heparin (UFH) and low-molecular-weight heparins (LMWHs) are widely
applied for surgical procedures and extracorporeal therapies, which, however, suffer …