The clinical and pathophysiological correlates of locus coeruleus (LC) degeneration in
Alzheimer's disease (AD) could be clarified using a method to index LC integrity in vivo …

Animals that consume fermenting fruit and nectar are at risk of exposure to ethanol and the
detrimental effects of inebriation. In this report, we show that the hormone FGF21, which is …

Abstract The “dorsal pons”, or “dorsal pontine tegmentum”(dPnTg), is part of the brainstem. It
is a complex, densely packed region whose nuclei are involved in regulating many vital …

Animal and human imaging research reported that the presence of cortical Alzheimer's
Disease's (AD) neuropathology, beta-amyloid and neurofibrillary tau, is associated with …

Patients with inflammatory bowel disease (IBD) suffer from depression at higher rates than
the general population. An etiological trigger of depressive symptoms is theorised to be …

Recent data demonstrate that noradrenergic neurons of the locus coeruleus (LC-NE) are
required for fear-induced suppression of feeding, but the role of endogenous LC-NE activity …

Previous studies have reported substantial involvement of the noradrenergic system in
Parkinson's disease. Neuromelanin-sensitive MRI sequences and PET tracers have become …

The noradrenaline (NA) system is one of the brain's major neuromodulatory systems; it
originates in a small midbrain nucleus, the locus coeruleus (LC), and projects widely …

Oligodendrocyte precursor cells (OPCs) generate oligodendrocytes, contributing to
myelination and myelin repair. OPCs contact axons and respond to neuronal activity, but …

Sleep is assumed to be a unitary, global state in humans and most other animals that is
coordinated by executive centers in the brain stem, hypothalamus, and basal forebrain …