Abstract Changes in dopaminergic neuromodulation play a key role in adult memory
decline. Recent research has also implicated noradrenaline in shaping late-life memory …

Social neuroscience has often been criticized for approaching the investigation of the neural
processes that enable social interaction and cognition from a passive, detached, third …

The supraspinal descending pain modulatory system (DPMS) shapes pain perception via
monoaminergic modulation of sensory information in the spinal cord. However, the role and …

The central noradrenergic (NA) system is critical for the maintenance of attention, behavioral
flexibility, spatial navigation, and learning and memory, those cognitive functions lost first in …

The earliest abnormality associated with Alzheimer's disease (AD) is the presence of
persistently phosphorylated pretangle tau in locus coeruleus (LC) neurons. LC neuron …

The locus coeruleus (LC) is a small brainstem structure located in the lower pons and is the
main source of noradrenaline (NA) in the brain. Via its phasic and tonic firing, it modulates …

Autopsy data indicate that the locus coeruleus (LC) is one of the first sites in the brain to
accumulate hyperphosphorylated tau pathology, with the rostral part possibly being more …

Background and purpose Human neuropathological studies indicate that the pontine
nucleus Locus Coeruleus (LC) undergoes significant and early degeneration in Alzheimer's …

Alzheimer's disease (AD) is the most common form of dementia. Obesity in middle age
increases AD risk and severity, which is alarming given that obesity prevalence peaks at …

Background The brainstem locus coeruleus (LC) constitutes the intersection of the initial
pathophysiological processes of Alzheimer's disease (AD) and sleep-wake dysregulation in …