Hyperphosphorylated tau in the locus coeruleus (LC) is ubiquitous in prodromal Alzheimer's
disease (AD), and LC neurons degenerate as AD progresses. Hyperphosphorylated tau …

In the present report, we evaluated adrenergic mechanisms of generalized spike-wave
epileptic discharges (SWDs), which are the encephalographic hallmarks of idiopathic …

Norepinephrine (NE) neurons in the locus coeruleus (LC) make long-range projections
throughout the central nervous system, playing critical roles in arousal and mood, as well as …

Aversive events can evoke strong emotions that trigger cerebral neuroactivity to facilitate
behavioral and cognitive shifts to secure physiological stability. However, upon intense …

Dementia remains one of the leading causes of morbidity and mortality in older adults.
Alzheimer's disease (AD) is the most common type of dementia, affecting over 55 million …

Abstract The hypothalamus and Locus Coeruleus (LC) share a variety of functions, as both
of them take part in the regulation of the sleep/wake cycle and in the modulation of …

Pupil size variations have been associated with changes in brain activity patterns related
with specific cognitive factors, such as arousal, attention, and mental effort. The locus …

The cerebral cortex generates flexible behavior by learning. Reinforcement learning is
thought to be driven by error signals in midbrain dopamine neurons. However, they project …

BACKGROUND The locus coeruleus (LC) is the primary source of norepinephrine in the
brain and regulates arousal and sleep. Animal research shows that it plays important roles …

Background: The locus coeruleus (LC) is one of the earliest brain regions to accumulate
hyperphosphorylated tau, but a lack of animal models that recapitulate this pathology has …