Spinal motoneuron firing depends greatly on persistent inward currents (PICs), which in turn
are facilitated by the neuromodulators serotonin and noradrenaline. The aim of this study …

Resilience represents an active adaption process in the face of adversity, trauma, tragedy,
threats, or significant sources of stress. Investigations of neurobiological mechanisms of …

Selective serotonin (5-HT) reuptake inhibitors are only 30% effective for remission in
subjects with major depression, and the best treatments for SSRI-resistant patients remain …

Objective The neurobehavioral underpinnings of binge‐eating disorder (BED), co‐occurring
with obesity (OB), are largely unknown. This research project conceptualizes BED as a …

Most memories that are formed are forgotten, while others are retained longer and are
subject to memory stabilization. We show that non-invasive transcutaneous electrical …

Breathing is a natural daily action that one cannot do without, and it sensitively and intensely
changes under various situations. What if this essential act of breathing can impact our …

Abstract Purpose of Review Performing a thorough review of magnetic resonance imaging
(MRI) studies assessing locus coeruleus (LC) integrity in ageing and Alzheimer's disease …

Parkinson's disease (PD) is characterized by motor impairments caused by degeneration of
dopamine neurons in the substantia nigra pars compacta. In addition to these symptoms, PD …

There is clear, early noradrenergic dysfunction in Alzheimer's disease. This is likely
secondary to pathological tau deposition in the locus coeruleus, the pontine nucleus that …

Unlike physiological stress, which carries survival value, pathological stress is widespread
in modern society and acts as a main risk factor for visceral pain. As the main stress …