In human skin, melanogenesis is a tightly regulated process. Indeed, several extracellular
signals are transduced via dedicated signalling pathways and mostly converge to MITF, a …

Waardenburg syndrome (WS) is characterized by the association of pigmentation
abnormalities, including depigmented patches of the skin and hair, vivid blue eyes or …

Malignant melanoma is a neoplasm of melanocytes, and the microphthalmia‐associated
transcription factor (MITF) is essential for the existence of melanocytes. MITF's relevance for …

In the light of substantial discoveries in epithelial and hair pigmentation pathophysiology,
this review summarizes the current understanding of skin pigmentation mechanisms …

Please cite this paper as:“Transcription physiology” of pigment formation in melanocytes:
central role of (MITF). Experimental Dermatology 2010; 19: 617–627. Abstract: Melanin …

Microphthalmia‐associated transcription factor (MITF) was initially shown to play a key role
in melanocyte differentiation through the direct transcriptional control of TYROSINASE …

Malignant melanoma is a chemotherapy‐resistant cancer with high mortality. Recent
advances in our understanding of the disease at the molecular level have indicated that it …

Melanogenesis is the unique process of producing pigmented biopolymers that are
sequestered within melanosomes, which provides color to the skin, hair and eyes of animals …

Human neurocristopathies include a number of syndromes, tumors, and dysmorphologies of
neural crest (NC) stem cell derivatives. In recent years, many white spotting genes have …

BRAF is a member of the RAF kinase family, which acts in the ERK/MAP kinase pathway, a
signalling cascade that regulates cellular proliferation, differentiation and survival. Single …