The extracellular matrix (ECM) is a complex network with multiple functions, including
specific functions during tissue regeneration. Precisely, the properties of the ECM have been …

The formation of new blood vessels, or angiogenesis, is a complex process that plays
important roles in growth and development, tissue and organ regeneration, as well as …

The placenta sits at the interface between the maternal and fetal vascular beds where it
mediates nutrient and waste exchange to enable in utero existence. Placental cells …

Mesenchymal stem cells (MSCs) have shown their therapeutic potency for treatment of
cardiovascular diseases owing to their low immunogenicity, ease of isolation and …

Critical limb ischemia (CLI), the most severe form of peripheral artery disease, is
characterized by pain at rest and non-healing ulcers in the lower extremities. For patients …

Rationale: Critical limb ischemia is a life-threatening complication of peripheral arterial
disease. In patients who are ineligible for revascularization procedures, there are few …

Stem cell transplantation via direct injection is a minimally invasive strategy being explored
for treatment of a variety of injuries and diseases. Injectable hydrogels with shear moduli< …

The age-adjusted prevalence of peripheral arterial disease in the US population has been
estimated to approach 12%. The clinical consequences of occlusive peripheral arterial …

Identification of the immunomodulatory and regenerative properties of mesenchymal stem
cells (MSCs) have made them an attractive alternative therapeutic option for diseases with …

Cell therapies aim to repair the mechanisms underlying disease initiation and progression,
achieved through trophic effect or by cell replacement. Multiple cell types can be utilized in …