[HTML][HTML] CAR-T cell therapy: current limitations and potential strategies
RC Sterner, RM Sterner - Blood cancer journal, 2021 - nature.com
Chimeric antigen receptor (CAR)-T cell therapy is a revolutionary new pillar in cancer
treatment. Although treatment with CAR-T cells has produced remarkable clinical responses …
treatment. Although treatment with CAR-T cells has produced remarkable clinical responses …
[HTML][HTML] Technical feasibility and physiological relevance of hypoxic cell culture models
J Pavlacky, J Polak - Frontiers in endocrinology, 2020 - frontiersin.org
Hypoxia is characterized as insufficient oxygen delivery to tissues and cells in the body and
is prevalent in many human physiology processes and diseases. Thus, it is an attractive …
is prevalent in many human physiology processes and diseases. Thus, it is an attractive …
Distinct transcription factor networks control neutrophil-driven inflammation
Neutrophils display distinct gene expression patters depending on their developmental
stage, activation state and tissue microenvironment. To determine the transcription factor …
stage, activation state and tissue microenvironment. To determine the transcription factor …
[HTML][HTML] High purity isolation of low density neutrophils casts doubt on their exceptionality in health and disease
GR Hardisty, F Llanwarne, D Minns, JL Gillan… - Frontiers in …, 2021 - frontiersin.org
Low density neutrophils (LDNs) are described in a number of inflammatory conditions,
cancers and infections and associated with immunopathology, and a mechanistic role in …
cancers and infections and associated with immunopathology, and a mechanistic role in …
CAR T-cell therapy: Reprogramming patient's immune cell to treat cancer
Chimeric antigen receptor (CAR)-T cell therapy is a game changer in cancer treatment.
Although CAR-T cell therapy has achieved significant clinical responses in specific …
Although CAR-T cell therapy has achieved significant clinical responses in specific …
[HTML][HTML] Hypoxic jumbo spheroids on-A-Chip (HOnAChip): Insights into treatment efficacy
Simple Summary Hypoxia is found in half of the solid cancers and is a major contributor to
treatment resistance and promotion of metastasis, leading to shortened patient survival. No …
treatment resistance and promotion of metastasis, leading to shortened patient survival. No …
[HTML][HTML] Development and validation of a novel immune-gene pairs prognostic model associated with CTNNB1 alteration in hepatocellular carcinoma
J Huo, L Wu, Y Zang - … medical journal of experimental and clinical …, 2020 - ncbi.nlm.nih.gov
Development and Validation of a Novel Immune-Gene Pairs Prognostic Model Associated with
CTNNB1 Alteration in Hepatocellular Carcinoma - PMC Back to Top Skip to main content NIH …
CTNNB1 Alteration in Hepatocellular Carcinoma - PMC Back to Top Skip to main content NIH …
[HTML][HTML] Mathematical Modeling of Cellular Processes: Integration of quantitative methods and mathematical approaches for the modeling of cancer cell proliferation …
Physiological processes rely on the control of cell proliferation, and the dysregulation of
these processes underlies various pathological conditions, including cancer. Mathematical …
these processes underlies various pathological conditions, including cancer. Mathematical …
Targeting CEACAM5/6 With a Novel Dual Specific Antibody-Drug Conjugate as a Therapeutic Strategy in Gastrointestinal Cancers
KA Cardenas - 2023 - search.proquest.com
Background: Carcinoembryonic antigen cell adhesion molecule (CEACAM) family members
5 and 6 are tumor-associated antigens frequently upregulated in epithelial cancers …
5 and 6 are tumor-associated antigens frequently upregulated in epithelial cancers …