[HTML][HTML] ROS generation in microglia: understanding oxidative stress and inflammation in neurodegenerative disease
DSA Simpson, PL Oliver - Antioxidants, 2020 - mdpi.com
Neurodegenerative disorders, such as Alzheimer's disease, are a global public health
burden with poorly understood aetiology. Neuroinflammation and oxidative stress (OS) are …
burden with poorly understood aetiology. Neuroinflammation and oxidative stress (OS) are …
[HTML][HTML] The pivotal role of NF-kB in the pathogenesis and therapeutics of Alzheimer's disease
Alzheimer's Disease (AD) is the most common neurodegenerative disease worldwide, with a
high prevalence that is expected to double every 20 years. Besides the formation of Aβ …
high prevalence that is expected to double every 20 years. Besides the formation of Aβ …
[HTML][HTML] Astrocytes and oligodendrocytes undergo subtype-specific transcriptional changes in Alzheimer's disease
Resolving glial contributions to Alzheimer's disease (AD) is necessary because changes in
neuronal function, such as reduced synaptic density, altered electrophysiological properties …
neuronal function, such as reduced synaptic density, altered electrophysiological properties …
[HTML][HTML] Alzheimer's disease: an update and insights into pathophysiology
Alzheimer's disease (AD) is an irreversible brain disorder associated with slow, progressive
loss of brain functions mostly in older people. The disease processes start years before the …
loss of brain functions mostly in older people. The disease processes start years before the …
[HTML][HTML] Neuroinflammation in Alzheimer's disease
IG Onyango, GV Jauregui, M Čarná, JP Bennett Jr… - Biomedicines, 2021 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disease associated with human aging.
Ten percent of individuals over 65 years have AD and its prevalence continues to rise with …
Ten percent of individuals over 65 years have AD and its prevalence continues to rise with …
[HTML][HTML] The microbiota–gut–brain axis and Alzheimer's disease: neuroinflammation is to blame?
A Megur, D Baltriukienė, V Bukelskienė, A Burokas - Nutrients, 2020 - mdpi.com
For years, it has been reported that Alzheimer's disease (AD) is the most common cause of
dementia. Various external and internal factors may contribute to the early onset of AD. This …
dementia. Various external and internal factors may contribute to the early onset of AD. This …
[HTML][HTML] Astrocytes: role and functions in brain pathologies
Astrocytes are a population of cells with distinctive morphological and functional
characteristics that differ within specific areas of the brain. Postnatally, astrocyte progenitors …
characteristics that differ within specific areas of the brain. Postnatally, astrocyte progenitors …
[HTML][HTML] Tau oligomer induced HMGB1 release contributes to cellular senescence and neuropathology linked to Alzheimer's disease and frontotemporal dementia
Aging, pathological tau oligomers (TauO), and chronic inflammation in the brain play a
central role in tauopathies, including Alzheimer's disease (AD) and frontotemporal dementia …
central role in tauopathies, including Alzheimer's disease (AD) and frontotemporal dementia …
A tetravalent TREM2 agonistic antibody reduced amyloid pathology in a mouse model of Alzheimer's disease
Triggering receptor expressed on myeloid cells 2 (TREM2) plays crucial roles in Alzheimer's
disease (AD) by regulating microglia migration toward, and phagocytosis of oligomeric …
disease (AD) by regulating microglia migration toward, and phagocytosis of oligomeric …
Neuroprotective mechanisms of resveratrol in Alzheimer's disease: role of SIRT1
BAQ Gomes, JPB Silva, CFR Romeiro… - Oxidative medicine …, 2018 - Wiley Online Library
Alzheimer's disease (AD) is a progressive and neurodegenerative disorder of the cortex and
hippocampus, which eventually leads to cognitive impairment. Although the etiology of AD …
hippocampus, which eventually leads to cognitive impairment. Although the etiology of AD …