[HTML][HTML] Advanced bioinformatics tools in the pharmacokinetic profiles of natural and synthetic compounds with anti-diabetic activity

AM Udrea, G Gradisteanu Pircalabioru, AA Boboc… - Biomolecules, 2021 - mdpi.com
Diabetes represents a major health problem, involving a severe imbalance of blood sugar
levels, which can disturb the nerves, eyes, kidneys, and other organs. Diabes management …

[HTML][HTML] Network Pharmacology Study to Reveal the Potentiality of a Methanol Extract of Caesalpinia sappan L. Wood against Type-2 Diabetes Mellitus

M Adnan, BB Jeon, MHU Chowdhury, KK Oh, T Das… - Life, 2022 - mdpi.com
Caesalpinia sappan L.(CS) is widely used to treat diabetic complications in south-east Asia,
specifically in traditional Chinese medicine. This study intends to explain the molecular …

Structural analysis, virtual screening and molecular simulation to identify potential inhibitors targeting 2'-O-ribose methyltransferase of SARS-CoV-2 coronavirus

Y Jiang, L Liu, M Manning, M Bonahoom… - Journal of …, 2022 - Taylor & Francis
Abstract SARS-CoV-2, an emerging coronavirus, has spread rapidly around the world,
resulting in over ten million cases and more than half a million deaths as of July 1, 2020 …

[HTML][HTML] Preparation of puerarin chitosan oral nanoparticles by ionic gelation method and its related kinetics

J Yan, ZY Guan, WF Zhu, LY Zhong, ZQ Qiu, PF Yue… - Pharmaceutics, 2020 - mdpi.com
In this paper, as an active ingredient, puerarin chitosan nanoparticles (Pur-CS/TPP-NPs) are
prepared by an ionic gelation method. The chitosan (CS) concentration, pH of the CS …

[HTML][HTML] Anticancer Potential of Flavonoids: An Overview with an Emphasis on Tangeretin

FCF de Luna, WAS Ferreira, SMM Casseb… - Pharmaceuticals, 2023 - mdpi.com
Natural compounds with pharmacological activity, flavonoids have been the subject of an
exponential increase in studies in the field of scientific research focused on therapeutic …

Puerarin induces mouse mesenteric vasodilation and ameliorates hypertension involving endothelial TRPV4 channels

T Zhou, Z Wang, M Guo, K Zhang, L Geng, A Mao… - Food & function, 2020 - pubs.rsc.org
Puerarin (Pue) is an isoflavone derived from the root of Pueraria lobata, which has been
widely used as food and a herb for treating cardiovascular and cerebrovascular diseases …

[HTML][HTML] Yishen Huashi granules ameliorated the development of diabetic nephropathy by reducing the damage of glomerular filtration barrier

T Zhao, M Li, Q Xiang, B Lie, D Chen… - Frontiers in …, 2022 - frontiersin.org
Background: Diabetic nephropathy (DN) is one of the most common complications of
diabetes and the primary cause of end-stage renal disease. At present, renin–angiotensin …

[HTML][HTML] Integrative analysis of metabolome and transcriptome reveals the mechanism of color formation in cassava (Manihot esculenta Crantz) leaves

X Luo, F An, J Xue, W Zhu, Z Wei, W Ou, K Li… - Frontiers in Plant …, 2023 - frontiersin.org
Cassava (Manihot esculenta Crantz) leaves are often used as vegetables in Africa.
Anthocyanins possess antioxidant, anti-inflammatory, anti-cancer, and other biological …

[HTML][HTML] Size-dependent adsorption performance of ZnO nanoclusters for drug delivery applications

M Kurban, İ Muz - Structural Chemistry, 2023 - Springer
We have investigated the size-dependent adsorption performance of ZnO nanoclusters
(NCs) as drug delivery carriers for the first time. Our results show that the adsorption energy …

Synthesis of new halogenated flavonoid-based isoxazoles: In vitro and in silico evaluation of a-amylase inhibitory potential, a SAR analysis and DFT studies

I Saidi, M Manachou, M Znati, J Bouajila… - Journal of Molecular …, 2022 - Elsevier
Carbohydrates are the main source of calories in most diets, and α-amylase is considered
one of the main enzymes that initiate their digestion. The inhibition of α-amylase is therefore …