Genome-scale metabolic network models for industrial microorganisms metabolic engineering: current advances and future prospects
Z Gong, J Chen, X Jiao, H Gong, D Pan, L Liu… - Biotechnology …, 2024 - Elsevier
The construction of high-performance microbial cell factories (MCFs) is the centerpiece of
biomanufacturing. However, the complex metabolic regulatory network of microorganisms …
biomanufacturing. However, the complex metabolic regulatory network of microorganisms …
Design of microbial catalysts for two-stage processes
Microbial catalysts must partition incoming substrate between the synthesis of biomass and
the synthesis of a desired product. Although biomass synthesis generates more catalyst and …
the synthesis of a desired product. Although biomass synthesis generates more catalyst and …
Systematic design and in vitro validation of novel one-carbon assimilation pathways
The utilization of one-carbon (C 1) assimilation pathways to produce chemicals and fuels
from low-cost C 1 compounds could greatly reduce the substrate-related production costs …
from low-cost C 1 compounds could greatly reduce the substrate-related production costs …
A Novel Cyanobacterium Synechococcus elongatus PCC 11802 has Distinct Genomic and Metabolomic Characteristics Compared to its Neighbor PCC 11801
Cyanobacteria, a group of photosynthetic prokaryotes, are attractive hosts for
biotechnological applications. It is envisaged that future biorefineries will deploy engineered …
biotechnological applications. It is envisaged that future biorefineries will deploy engineered …
[HTML][HTML] Cycling between growth and production phases increases cyanobacteria bioproduction of lactate
K Shabestary, HP Hernández, R Miao, E Ljungqvist… - Metabolic …, 2021 - Elsevier
Decoupling growth from product synthesis is a promising strategy to increase carbon
partitioning and maximize productivity in cell factories. However, reduction in both substrate …
partitioning and maximize productivity in cell factories. However, reduction in both substrate …
Kinetic modeling of the Calvin cycle identifies flux control and stable metabolomes in Synechocystis carbon fixation
M Janasch, J Asplund-Samuelsson… - Journal of …, 2019 - academic.oup.com
Biological fixation of atmospheric CO2 via the Calvin–Benson–Bassham cycle has massive
ecological impact and offers potential for industrial exploitation, either by improving carbon …
ecological impact and offers potential for industrial exploitation, either by improving carbon …
Photosynthetic Co-production of Succinate and Ethylene in a Fast-Growing Cyanobacterium, Synechococcus elongatus PCC 11801
Cyanobacteria are emerging as hosts for photoautotrophic production of chemicals. Recent
studies have attempted to stretch the limits of photosynthetic production, typically focusing …
studies have attempted to stretch the limits of photosynthetic production, typically focusing …
OptMDFpathway: Identification of metabolic pathways with maximal thermodynamic driving force and its application for analyzing the endogenous CO2 fixation …
O Hädicke, A von Kamp, T Aydogan… - PLoS computational …, 2018 - journals.plos.org
Constraint-based modeling techniques have become a standard tool for the in silico
analysis of metabolic networks. To further improve their accuracy, recent methodological …
analysis of metabolic networks. To further improve their accuracy, recent methodological …
Integrating thermodynamic and enzymatic constraints into genome-scale metabolic models
Stoichiometric genome-scale metabolic network models (GEMs) have been widely used to
predict metabolic phenotypes. In addition to stoichiometric ratios, other constraints such as …
predict metabolic phenotypes. In addition to stoichiometric ratios, other constraints such as …
Large-scale kinetic metabolic models of Pseudomonas putida KT2440 for consistent design of metabolic engineering strategies
Background Pseudomonas putida is a promising candidate for the industrial production of
biofuels and biochemicals because of its high tolerance to toxic compounds and its ability to …
biofuels and biochemicals because of its high tolerance to toxic compounds and its ability to …