[HTML][HTML] Lipoprotein (a) beyond the kringle IV repeat polymorphism: the complexity of genetic variation in the LPA gene

S Coassin, F Kronenberg - Atherosclerosis, 2022 - Elsevier
Abstract High lipoprotein (a)[Lp (a)] concentrations are one of the most important genetically
determined risk factors for cardiovascular disease. Lp (a) concentrations are an enigmatic …

[HTML][HTML] Structure, function, and genetics of lipoprotein (a)

K Schmidt, A Noureen, F Kronenberg… - Journal of lipid …, 2016 - ASBMB
Lipoprotein (a)[Lp (a)] has attracted the interest of researchers and physicians due to its
intriguing properties, including an intragenic multiallelic copy number variation in the LPA …

Lipoprotein (a) concentration and risks of cardiovascular disease and diabetes

DF Gudbjartsson, G Thorgeirsson, P Sulem… - Journal of the American …, 2019 - jacc.org
Abstract Background: Lipoprotein (a)[Lp (a)] is a causal risk factor for cardiovascular
diseases that has no established therapy. The attribute of Lp (a) that affects cardiovascular …

Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: findings from the pregnancy and childhood epigenetics (PACE) consortium

GC Sharp, LA Salas, C Monnereau… - Human molecular …, 2017 - academic.oup.com
Pre-pregnancy maternal obesity is associated with adverse offspring outcomes at birth and
later in life. Individual studies have shown that epigenetic modifications such as DNA …

[HTML][HTML] Lipoprotein (a): impact by ethnicity and environmental and medical conditions

B Enkhmaa, E Anuurad, L Berglund - Journal of lipid research, 2016 - ASBMB
Levels of lipoprotein (a)[Lp (a)], a complex between an LDL-like lipid moiety containing one
copy of apoB, and apo (a), a plasminogen-derived carbohydrate-rich hydrophilic protein, are …

[HTML][HTML] A genome-wide association meta-analysis on lipoprotein (a) concentrations adjusted for apolipoprotein (a) isoforms [S]

S Mack, S Coassin, R Rueedi, NA Yousri… - Journal of lipid …, 2017 - ASBMB
High lipoprotein (a)[Lp (a)] concentrations are an independent risk factor for cardiovascular
outcomes. Concentrations are strongly influenced by apo (a) kringle IV repeat isoforms. We …

Genome-Wide Association Study Highlights APOH as a Novel Locus for Lipoprotein(a) Levels—Brief Report

M Hoekstra, HY Chen, J Rong, L Dufresne… - … , and vascular biology, 2021 - Am Heart Assoc
Objective: Lp (a)(lipoprotein [a]) is an independent risk factor for cardiovascular diseases
and plasma levels are primarily determined by variation at the LPA locus. We performed a …

Translating genome-wide association findings into new therapeutics for psychiatry

G Breen, Q Li, BL Roth, P O'donnell, M Didriksen… - Nature …, 2016 - nature.com
Genome-wide association studies (GWAS) in psychiatry, once they reach sufficient sample
size and power, have been enormously successful. The Psychiatric Genomics Consortium …

LPA Variants Are Associated With Residual Cardiovascular Risk in Patients Receiving Statins

WQ Wei, X Li, Q Feng, M Kubo, IJ Kullo, PL Peissig… - Circulation, 2018 - Am Heart Assoc
Background: Coronary heart disease (CHD) is a leading cause of death globally. Although
therapy with statins decreases circulating levels of low-density lipoprotein cholesterol and …

[HTML][HTML] Deep coverage whole genome sequences and plasma lipoprotein (a) in individuals of European and African ancestries

SM Zekavat, S Ruotsalainen, RE Handsaker… - Nature …, 2018 - nature.com
Abstract Lipoprotein (a), Lp (a), is a modified low-density lipoprotein particle that contains
apolipoprotein (a), encoded by LPA, and is a highly heritable, causal risk factor for …