The regulation of Lp (a) clearance from circulation by cellular uptake remains enigmatic.
While multiple receptors have been implicated in Lp (a) uptake, each receptor only partially …

Familial hypercholesterolaemia (FH) causes cardiovascular disease from a young age, due
to extremely high plasma concentrations of LDL-cholesterol. This thesis examines (1) the …

Both genetic and environmental factors contribute to the different biological processes which
underlie clinical coronary artery disease (CAD), including atherosclerosis, thrombosis …

Background: Left untreated, calcific aortic stenosis (AS) culminates in heart failure and
death. Aortic valve replacement remains the only treatment option but is not indicated for …

Background Mutations in the solute carrier family 22 member 3 (SLC22A3), lipoprotein (a)-
like 2 (LPAL2), and the lipoprotein (a)(LPA) gene cluster, which encodes apolipoprotein …

Coronary artery disease (CAD) is the leading cause of death worldwide. Pakistan faces a
high epidemic of CAD, and the disease burden is increasing with the passage of time …

Abstract Lipoprotein (a), Lp (a), a complex between a low-density lipoprotein (LDL)-like lipid
moiety containing one copy of apolipoprotein (apo) B, and apo (a), a plasminogen-derived …

Department of Molecular Medicine, Lipid Clinic and Atherosclerosis Prevention
Centre,'Umberto I'Hospital–'Sapienza'University of Rome, Rome, Italy (Drs Stefanutti, Di …

Two intriguing forms of genome structural variation (SV)–dispersed duplications, and de
novo rearrangements of complex, multi-allelic loci–have long escaped genomic analysis …