Cisplatin is one of the most potent antitumor agents known, displaying clinical activity
against a wide variety of solid tumors. Its cytotoxic mode of action is mediated by its …

The causal role of human papillomavirus infections in cervical cancer has been documented
beyond reasonable doubt. The association is present in virtually all cervical cancer cases …

The p53 tumor-suppressor protein functions as a transcriptional activator, and several p53-
inducible genes that play a role in the induction of apoptosis in response to p53 have been …

Papillomaviruses induce benign and malignant epithelial tumors, and the viral E6
oncoprotein is essential for full transformation. E6 contributes to transformation by …

Multiple genetic changes occur during the evolution of normal cells into cancer cells. This
evolution is facilitated in cancer cells by loss of fidelity in the processes that replicate, repair …

The papillomavirus family represents a remarkably heterogeneous group of viruses. At
present, 77 distinct genotypes have been identified in humans and partial sequences have …

The cell cycle is a complex process that involves numerous regulatory proteins that direct
the cell through a specific sequence of events culminating in mitosis and the production of …

There are more than half a million incident cases of squamous-cell carcinoma of the head
and neck worldwide each year, primarily affecting the oropharynx, oral cavity, hypopharynx …

The tumor suppressor p53 is a cell cycle checkpoint protein that contributes to the
preservation of genetic stability by mediating either a G1 arrest or apoptosis in response to …

We describe a gene encoding p73, a protein that shares considerable homology with the
tumor suppressor p53. p73 maps to 1p36, a region frequently deleted in neuroblastoma and …